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1. (WO2010030810) CARBACEPHEM BETA-LACTAM ANTIBIOTICS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/030810    International Application No.:    PCT/US2009/056554
Publication Date: 18.03.2010 International Filing Date: 10.09.2009
IPC:
C07D 463/22 (2006.01), A61K 31/4353 (2006.01), A61P 31/04 (2006.01)
Applicants: ACHAOGEN, INC. [US/US]; 7000 Shoreline Court, 3rd Floor South San Francisco, CA 94080 (US) (For All Designated States Except US).
WAGMAN, Allan, Scott [US/US]; (US) (For US Only).
MOSER, Heinz, Ernst [CH/US]; (US) (For US Only)
Inventors: WAGMAN, Allan, Scott; (US).
MOSER, Heinz, Ernst; (US)
Agent: WAGNER, Emily, W.; (US)
Priority Data:
61/095,827 10.09.2008 US
61/171,678 22.04.2009 US
Title (EN) CARBACEPHEM BETA-LACTAM ANTIBIOTICS
(FR) ANTIBIOTIQUES DE TYPE BÉTA-LACTAME À BASE DE CARBACÉPHÈME
Abstract: front page image
(EN)Carbacephem β-lactam antibiotics having structure (I) are disclosed, including stereoisomers, pharmaceutically acceptable salts, esters and prodrugs thereof, wherein Ar2, X, R1 and R2 are as defined herein. The compounds are useful for the treatment of bacterial infections, in particular those caused by methicillin-resistant Staphylococcus spp.
(FR)La présente invention concerne des antibiotiques de type b-lactame à base de carbacéphème ayant la structure (I), comprenant les stéréoisomères, sels pharmaceutiquement acceptables, esters et promédicaments de ceux-ci, dans laquelle Ar2, X, R1 et R2 sont tels que définis ici. Les composés sont utiles dans le traitement d'infections bactériennes, en particulier celles causées par les espèces de Staphylococcus résistantes à la méthicilline.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)