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1. WO2010030787 - ESTROGEN RECEPTOR LIGANDS

Publication Number WO/2010/030787
Publication Date 18.03.2010
International Application No. PCT/US2009/056521
International Filing Date 10.09.2009
IPC
C07C 323/20 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
323Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
10containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
18having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
20with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
C07C 39/16 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
39Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
12polycyclic with no unsaturation outside the aromatic rings
15with all hydroxy groups on non-condensed rings
16Bis(hydroxy phenyl)alkanes; Tris(hydroxy phenyl)alkanes
C07C 39/367 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
39Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
24Halogenated derivatives
367polycyclic non-condensed, containing only six-membered aromatic rings, e.g. halogenated poly-(hydroxy-phenyl)alkanes
A61K 31/05 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
05Phenols
A61K 31/055 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
05Phenols
055the aromatic ring being substituted by halogen
A61K 31/10 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
095Sulfur, selenium or tellurium compounds, e.g. thiols
10Sulfides; Sulfoxides; Sulfones
CPC
A61P 5/32
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
5Drugs for disorders of the endocrine system
24of the sex hormones
32Antioestrogens
C07C 2601/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2601Systems containing only non-condensed rings
06with a five-membered ring
08the ring being saturated
C07C 2601/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2601Systems containing only non-condensed rings
12with a six-membered ring
14The ring being saturated
C07C 323/20
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
323Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
10containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
18having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
20with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
C07C 39/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
39Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
12polycyclic with no unsaturation outside the aromatic rings
15with all hydroxy groups on non-condensed rings ; , e.g. phenylphenol
16Bis-(hydroxyphenyl) alkanes; Tris-(hydroxyphenyl)alkanes
C07C 39/367
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
39Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
24Halogenated derivatives
367polycyclic non-condensed, containing only six-membered aromatic rings as cyclic parts, e.g. halogenated poly-hydroxyphenylalkanes
Applicants
  • THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS [US]/[US] (AllExceptUS)
  • KATZENELLENBOGEN, John, A. [US]/[US] (UsOnly)
Inventors
  • KATZENELLENBOGEN, John, A.
Agents
  • ABELLEIRA, Susan, M.
Priority Data
61/191,63910.09.2008US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) ESTROGEN RECEPTOR LIGANDS
(FR) LIGANDS DU RÉCEPTEUR DES ŒSTROGÈNES
Abstract
(EN) The invention described herein discloses bisphenol alkane compounds of formulae III and Vl and similar compounds as well as 4-[4-hydroxybenzylthio]- phenol compounds which are estrogen receptor ligands, composition containing these compounds and methods for treating various conditions using the compounds and compositions of this invention.
(FR) L'invention concerne des composés de bisphénol-alcane de formules (III) et (VI) et des composés similaires, ainsi que des composés de 4-[4-hydroxybenzylthio]-phénol qui sont des ligands du récepteur des œstrogènes; une composition contenant ces composés et des méthodes de traitement de divers états pathologiques utilisant les composés et compositions de l'invention.
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