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1. (WO2010030781) AROMATIC CARBOXYLIC ACID DERIVATIVES FOR TREATMENT AND PROPHYLAXIS OF GASTROINTESTINAL DISEASES INCLUDING COLON CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/030781    International Application No.:    PCT/US2009/056515
Publication Date: 18.03.2010 International Filing Date: 10.09.2009
IPC:
C07C 311/45 (2006.01), C07C 309/26 (2006.01), C07C 245/08 (2006.01), C07D 311/58 (2006.01), C07D 311/36 (2006.01), A61K 31/18 (2006.01), A61K 31/185 (2006.01), A61P 1/04 (2006.01), A61P 35/00 (2006.01)
Applicants: NUMED INTERNATIONAL, INC. [US/US]; 216 Coltsgate Drive Cary, NC 27511 (US) (For All Designated States Except US).
EKWURIBE, Nnochiri [NG/US]; (US) (For US Only)
Inventors: EKWURIBE, Nnochiri; (US)
Agent: BRADIN, David, S.; INTELLECTUAL PROPERTY/TECHNOLOGY LAW P.O. Box 14329 Research Triangle Park, NC 27709 (US)
Priority Data:
61/095,668 10.09.2008 US
Title (EN) AROMATIC CARBOXYLIC ACID DERIVATIVES FOR TREATMENT AND PROPHYLAXIS OF GASTROINTESTINAL DISEASES INCLUDING COLON CANCER
(FR) DÉRIVÉS ACIDES CARBOXYLIQUES AROMATIQUES DESTINÉS AU TRAITEMENT ET À LA PROPHYLAXIE DE MALADIES GASTRO-INTESTINALES COMPRENANT LE CANCER DU COLON
Abstract: front page image
(EN)Prodrug compounds which metabolize into 5-ASA or analogs thereof, and taurine or analogs thereof, in the colon site are disclosed. Pharmaceutical compositions including the compounds, and methods of treatment using the compounds, are also disclosed. Such compounds have utility for treating or preventing gastrointestinal disorders, including colon cancer, ulcerative colitis and Crohn's disease.
(FR)La présente invention concerne des composés promédicaments qui se métabolisent en 5-ASA ou en ses analogues, et en taurine ou en ses analogues, dans le site du colon. L'invention concerne également des compositions pharmaceutiques comprenant les composés, et des procédés de traitement utilisant les composés. De tels composés sont utiles pour traiter ou prévenir des troubles gastro-intestinaux, comprenant le cancer du colon, la rectocolite hémorragique et la maladie de Crohn.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)