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Machine translation
1. (WO2010030735) STABILIZED COATING FOR PHARMACEUTICAL FORMULATIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/030735    International Application No.:    PCT/US2009/056451
Publication Date: 18.03.2010 International Filing Date: 10.09.2009
IPC:
A61K 9/30 (2006.01), A61K 9/16 (2006.01), A61P 9/12 (2006.01), A61K 31/44 (2006.01)
Applicants: AETHOS PHARMACEUTICALS, INC. [US/US]; 6101 Johns Road, Suite 8 Tampa, FL 33634 (US) (For All Designated States Except US).
MCMILLAN, Brian Robert [US/US]; (US) (For US Only).
DAVIAU, Todd Roland [US/US]; (US) (For US Only).
CRONAN, JR., John M. [US/US]; (US) (For US Only).
DAVIS, III, James Franklin [US/US]; (US) (For US Only).
LICARDE, Marke James [US/US]; (US) (For US Only).
TRIVEDI, Saurabh Sundhir [US/US]; (US) (For US Only).
COTTRELL, Ian W. [US/US]; (US) (For US Only)
Inventors: MCMILLAN, Brian Robert; (US).
DAVIAU, Todd Roland; (US).
CRONAN, JR., John M.; (US).
DAVIS, III, James Franklin; (US).
LICARDE, Marke James; (US).
TRIVEDI, Saurabh Sundhir; (US).
COTTRELL, Ian W.; (US)
Agent: KITCHELL, Barbara S.; (US)
Priority Data:
61/096,124 11.09.2008 US
Title (EN) STABILIZED COATING FOR PHARMACEUTICAL FORMULATIONS
(FR) ENROBAGE STABILISÉ DESTINÉ À DES FORMULATIONS PHARMACEUTIQUES
Abstract: front page image
(EN)A process is described for preparing stabilized tablet formulations for temperature and moisture sensitive active drugs. Water soluble polyvinyl alcohol is processed with drugs such as angiotensin converting enzyme (ACE) inhibitors and compressed into solid form once excess water is removed. Low dose polyvinyl alcohol ramipril tablets prepared by this process are stable under conditions of high humidity and heat for periods of at least up to six months with less than 8% hydrolysis of the prodrug to the active metabolite diketopiperazine (DKP).
(FR)La présente invention concerne un procédé permettant de préparer des formulations de comprimé stabilisées pour des médicaments actifs sensibles à la température et à l'humidité. Un alcool polyvinylique hydrosoluble est transformé avec des médicaments tels que des inhibiteurs de l'enzyme de conversion de l'angiotensine (ACE) et compressé en une forme solide une fois l'excès d'eau enlevé. Les comprimés de ramipril-alcool polyvinylique faiblement dosés préparés par ce procédé sont stables dans des conditions d'humidité et de chaleur élevées pendant des durées pouvant atteindre six mois avec moins de 8 % d'hydrolyse du promédicament en métabolite actif, la dicétopipérazine (DKP).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)