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1. (WO2010030670) COMPOSITIONS AND METHODS FOR THE PREVENTION OF OXIDATIVE DEGRADATION OF PROTEINS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/030670    International Application No.:    PCT/US2009/056365
Publication Date: 18.03.2010 International Filing Date: 09.09.2009
IPC:
A61K 38/29 (2006.01), A61K 47/18 (2006.01)
Applicants: GENENTECH, INC. [US/US]; 1 DNA Way South San Francisco, CA 94080 (US) (AE, AG, AM, AO, AU, AZ, BB, BF, BH, BJ, BR, BW, BY, BZ, CA, CF, CG, CI, CL, CM, CO, CR, CU, DM, DO, DZ, EC, EG, GA, GD, GE, GH, GM, GN, GQ, GT, GW, HN, ID, IL, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LY, MA, MD, ME, MG, ML, MN, MR, MW, MX, MY, MZ, NA, NE, NG, NI, NZ, OM, PE, PG, PH, RU, SC, SD, SG, SL, SN, ST, SV, SY, SZ, TD, TG, TJ, TM, TN, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
F. HOFFMANN-LA ROCHE AG; Grenzacherstrasse 124 4070 Basel (CH) (AL, AT, BA, BE, BG, CH, CN, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IN, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR only).
JI, Junyan, A. [US/US]; (US) (For US Only).
WANG, Yuchang, John [US/US]; (US) (For US Only).
ZHANG, Boyan [CA/US]; (US) (For US Only)
Inventors: JI, Junyan, A.; (US).
WANG, Yuchang, John; (US).
ZHANG, Boyan; (US)
Agent: DREGER, Ginger, R.; Arnold & Porter, LLP 1400 Page Mill Road Palo Alto, California 94303-1124 (US)
Priority Data:
61/095,878 10.09.2008 US
Title (EN) COMPOSITIONS AND METHODS FOR THE PREVENTION OF OXIDATIVE DEGRADATION OF PROTEINS
(FR) COMPOSITIONS ET PROCÉDÉS PERMETTANT D'ÉVITER LA DÉGRADATION OXYDATIVE DES PROTÉINES
Abstract: front page image
(EN)The invention relates to pharmaceutical formulations comprising a protein and free methionine in combination with one or more compounds capable of preventing the oxidation of aromatic amino acid residues within a protein. More specifically, the invention relates to stabilized, pharmaceutically effective preparations of oxidation-sensitive therapeutic agents. The invention further relates to a method of inhibiting the oxidation of such therapeutic agents.
(FR)L'invention concerne des formules pharmaceutiques contenant une protéine et de la méthionine libre en combinaison avec un ou plusieurs composés capables d'empêcher l'oxydation des résidus d'acides aminés aromatiques se trouvant dans une protéine. Plus précisément, l'invention concerne des préparations stabilisées efficaces sur le plan pharmaceutique contenant des agents thérapeutiques sensibles à l'oxydation. L'invention concerne en outre un procédé permettant d'inhiber l'oxydation de ces agents thérapeutiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)