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1. (WO2010030582) NOSCAPINE AND NOSCAPINE ANALOGS AND THEIR USE IN TREATING INFECTIOUS DISEASES BY TUBULIN BINDING INHIBITION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/030582    International Application No.:    PCT/US2009/056075
Publication Date: 18.03.2010 International Filing Date: 04.09.2009
IPC:
A61K 31/4355 (2006.01), A61P 31/12 (2006.01), A61P 31/16 (2006.01), A61P 31/18 (2006.01), A61P 31/04 (2006.01), A61P 31/10 (2006.01)
Applicants: EMORY UNIVERSITY [US/US]; Office Of Technology Transfer 1599 Clifton Road, 4th Floor Atlanta, GA 30322 (US) (For All Designated States Except US).
ACUFF, Cory [US/US]; (US) (For US Only).
KALMAN, Daniel [US/US]; (US) (For US Only)
Inventors: ACUFF, Cory; (US).
KALMAN, Daniel; (US)
Agent: BRADIN, David; Intellectual Property/technology Law P.O. box 14329 Research Triangle Park, NC 27709 (US)
Priority Data:
61/096,245 11.09.2008 US
Title (EN) NOSCAPINE AND NOSCAPINE ANALOGS AND THEIR USE IN TREATING INFECTIOUS DISEASES BY TUBULIN BINDING INHIBITION
(FR) NOSCAPINE ET ANALOGUES DE LA NOSCAPINE ET LEUR UTILISATION DANS LE TRAITEMENT DE MALADIES INFECTIEUSES PAR INHIBITION PAR LIAISON À LA TUBULINE
Abstract: front page image
(EN)Compositions and methods for treating or preventing infectious diseases, and inhibiting the ability of microbes to travel within mammalian cells, and inhibiting microbial replication, are disclosed. The compositions include various noscapine analogs, which are capable of blocking the movement of viruses and other microbes within mammalian and other cells by inhibiting the cytoplasmic transport mechanisms within the cells. The compositions described herein include an effective amount of the noscapine analogues described herein, along with a pharmaceutically acceptable carrier or excipient. The compositions can also include one or more additional antimicrobial compounds.
(FR)La présente invention concerne des compositions et des procédés de traitement ou de prévention de maladies infectieuses, et d'inhibition de la capacité des microbes à voyager dans les cellules de mammifères, et d'inhibition de la réplication microbienne. Les compositions comprennent divers analogues de la noscapine, qui sont capables de bloquer le mouvement de virus et d'autres microbes dans des cellules de mammifères et d'autres cellules en inhibant les mécanismes de transfert cytoplasmique à l'intérieur des cellules. Les compositions décrites ici comprennent une quantité efficace des analogues de la noscapine décrits ici, en association avec un transporteur ou un excipient pharmaceutiquement acceptable. Les compositions peuvent également comprendre un ou plusieurs composés antimicrobiens supplémentaires.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)