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Pub. No.:    WO/2010/030500    International Application No.:    PCT/US2009/054830
Publication Date: 18.03.2010 International Filing Date: 25.08.2009
C07D 471/04 (2006.01), C07D 487/04 (2006.01), A61K 31/437 (2006.01), A61K 31/519 (2006.01), A61P 9/00 (2006.01)
Applicants: BOEHRINGER INGELHEIM INTERNATIONAL GMBH [DE/DE]; Binger Strasse 173 55216 Ingelheim (DE) (For All Designated States Except US).
EMMANUEL, Michel, Jose [US/US]; (US) (For US Only).
GUO, Xin [CN/US]; (US) (For US Only).
KIM, Jin, Mi [CA/US]; (US) (For US Only).
LO, Ho, Yin [CN/US]; (US) (For US Only).
NEMOTO, Peter, Allen [US/US]; (US) (For US Only).
QIAN, Kevin, Chungeng [US/US]; (US) (For US Only)
Inventors: EMMANUEL, Michel, Jose; (US).
GUO, Xin; (US).
KIM, Jin, Mi; (US).
LO, Ho, Yin; (US).
NEMOTO, Peter, Allen; (US).
QIAN, Kevin, Chungeng; (US)
Agent: MORRIS, Michael P.; (US)
Priority Data:
61/095,335 09.09.2008 US
Abstract: front page image
(EN)Disclosed are small molecule inhibitors of the formula (I): and the pharmaceutical compositions thereof and processes of making the same. The compounds are useful in treating various diseases and conditions involving chymase.
(FR)La présente invention concerne des inhibiteurs de petite taille de formule (I) : et leurs compositions pharmaceutiques et leurs procédés de fabrication. Les composés sont utiles pour traiter des maladies et états divers impliquant la chymase.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)