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1. (WO2010030314) ABERRANT EXPRESSION OF CKS1 AND CKS2 AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/030314    International Application No.:    PCT/US2009/003069
Publication Date: 18.03.2010 International Filing Date: 18.05.2009
IPC:
A61K 38/43 (2006.01), A61P 35/00 (2006.01)
Applicants: THE TEXAS A&M UNIVERSITY SYSTEM [US/US]; 3369 Tamu College Station, TX 77843-3369 (US) (For All Designated States Except US)
Inventors: WANG, Fen; (US).
LAN, Yongshen; (US)
Agent: ADLER, Benjamin, Aaron, Ph. D., J.D.; Adler & Associates 8011 Candle Ln. Houston, TX 77071 (US)
Priority Data:
61/127,924 16.05.2008 US
Title (EN) ABERRANT EXPRESSION OF CKS1 AND CKS2 AND USES THEREOF
(FR) EXPRESSION ABERRANTE DE CKS1 ET CKS2 ET LEURS UTILISATIONS
Abstract: front page image
(EN)The present invention is drawn to providing a therapeutic strategy for prostate cancer. In this regard, the present invention demonstrates that elevated expression of Cks1 contributes to tumorigenicity of prostate tumor cells by promoting cell growth and elevated expression of Cks2 protects cells from apoptosis. Accordingly, the present invention discloses methods to diagnose and treat prostate cancer by targeting expression of Cks1 and Cks2 proteins.
(FR)L’invention concerne uns stratégie thérapeutique destinée au cancer de la prostate. A cet effet, l’invention montre qu’une expression élevée de Cks1 contribue à la tumorigénicité  des cellules tumorales de la prostate par promotion de la croissance cellulaire, une expression élevée de Cks2 protégeant les cellules contre une apoptose. En conséquence, l’invention concerne des méthodes pour diagnostiquer et traiter le cancer de la prostate par ciblage de l’expression des protéines Cks1 et Cks2.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)