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1. (WO2010030167) METHOD OF DETECTION AND DIAGNOSIS OF ORAL AND NASOPHARYNGEAL CANCERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/030167    International Application No.:    PCT/MY2009/000140
Publication Date: 18.03.2010 International Filing Date: 08.09.2009
Chapter 2 Demand Filed:    12.07.2010    
IPC:
C12Q 1/68 (2006.01), A61K 39/395 (2006.01), C40B 40/10 (2006.01), A61K 31/7105 (2006.01), A61P 35/00 (2006.01), G01N 33/574 (2006.01), A61K 38/17 (2006.01), C40B 40/08 (2006.01), G01N 33/68 (2006.01)
Applicants: CANCER RESEARCH INITIATIVE FOUNDATION [MY/MY]; 2nd Floor, Outpatient Centre Subang Jaya Medical Centre Selangor Darul Ehsan 475000 Selangor Jaya (MY) (For All Designated States Except US).
TEO, Soo-Hwang [MY/MY]; (MY) (For US Only).
CHEONG, Sok Ching [MY/MY]; (MY) (For US Only).
GAN, Chai Phei [MY/MY]; (MY) (For US Only).
MOHD ZAIN, Rosnah [MY/MY]; (MY) (For US Only)
Inventors: TEO, Soo-Hwang; (MY).
CHEONG, Sok Ching; (MY).
GAN, Chai Phei; (MY).
MOHD ZAIN, Rosnah; (MY)
Agent: SU, Siew Ling; Tay & Partners 6th Floor, Plaza See Hoy Chan Jalan Raja Chulan 50200 Kuala Lumpur (MY)
Priority Data:
PI20083548 12.09.2008 MY
Title (EN) METHOD OF DETECTION AND DIAGNOSIS OF ORAL AND NASOPHARYNGEAL CANCERS
(FR) PROCÉDÉ DE DÉTECTION ET DIAGNOSTIC DE CANCERS BUCCAUX ET RHINO-PHARYNGIENS
Abstract: front page image
(EN)The present invention relates to cancer and in particular to oral and nasopharyngeal cancers. In particular, the present invention relates to a method of detection and diagnosis of oral squamous cell carcinoma (OSCC) and nasopharyngeal cancers by determining the expression levels of certain genes. The method comprising (a) determining in a biological sample from the patient the amount of the expression level of at least one gene selected from the group consisting of GNA-12 and IFITM3; and (b) comparing the determined expression levels of said genes in said biological sample with the level in a reference. The invention also relates to polypeptides, antibodies and nucleic acids of the invention for use in medicine and a kit for performing the invention.
(FR)La présente invention concerne le cancer et en particulier les cancers buccaux et rhino-pharyngiens. En particulier, la présente invention concerne un procédé de détection et de diagnostic du carcinome malpighien buccal (OSCC) et des cancers rhino-pharyngiens par détermination des taux d’expression de certains gènes. Le procédé comprend (a) la détermination dans un échantillon biologique du patient de la quantité du taux d’expression d’au moins un gène choisi dans le groupe constitué de GNA-12 et IFITM3 ; et (b) la comparaison des taux d’expression déterminés desdits gènes dans ledit échantillon biologique au taux dans une référence. L’invention concerne en outre des polypeptides, des anticorps et des acides nucléiques de l’invention pour utilisation en médecine et un kit pour appliquer l’invention.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)