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Machine translation
1. (WO2010029513) PCSK9 ANTAGONISTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/029513    International Application No.:    PCT/IB2009/053990
Publication Date: 18.03.2010 International Filing Date: 11.09.2009
Chapter 2 Demand Filed:    12.02.2010    
IPC:
A61K 39/395 (2006.01), A61P 3/06 (2006.01), C07K 16/40 (2006.01)
Applicants: RINAT NEUROSCIENCE CORPORATION [US/US]; 230 East Grand Avenue South San Francisco, CA 94080 (US) (For All Designated States Except US).
LIANG, Hong [US/US]; (US) (For US Only).
ABDICHE, Yasmina Noubia [GB/US]; (US) (For US Only).
CHAPARRO RIGGERS, Javier Fernando [DE/US]; (US) (For US Only).
GOMES, Bruce Charles [US/US]; (US) (For US Only).
HAWKINS, Julie Jia Li [US/US]; (US) (For US Only).
PONS, Jaume [ES/US]; (US) (For US Only).
QIU, Xiayang [US/US]; (US) (For US Only).
STROP, Pavel [US/US]; (US) (For US Only).
WANG, Yuli [US/US]; (US) (For US Only).
PFIZER INC. [US/US]; 235 East 42nd Street New York, New York 10017 (US) (For All Designated States Except US)
Inventors: LIANG, Hong; (US).
ABDICHE, Yasmina Noubia; (US).
CHAPARRO RIGGERS, Javier Fernando; (US).
GOMES, Bruce Charles; (US).
HAWKINS, Julie Jia Li; (US).
PONS, Jaume; (US).
QIU, Xiayang; (US).
STROP, Pavel; (US).
WANG, Yuli; (US)
Agent: KLEIMAN, Gabriel L.; Pfizer Inc. 235 East 42nd Street New York, NY 10017 (US)
Priority Data:
61/096,716 12.09.2008 US
61/232,161 07.08.2009 US
61/235,643 20.08.2009 US
Title (EN) PCSK9 ANTAGONISTS
(FR) ANTAGONISTES DE PCSK9
Abstract: front page image
(EN)The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acid. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease, including treatment of hypercholesterolemia.
(FR)La présente invention concerne des anticorps antagonisants, des parties de liaison avec l'antigène de ces anticorps, et des aptamères qui se lient à la proprotéine convertase subtilisine/kexine de type 9 (PCSK9). L'invention concerne également des anticorps dirigés contre des peptides, où les anticorps se lient à PCSK9. L'invention concerne en outre un procédé permettant d'obtenir de tels anticorps et un acide nucléique codant pour les anticorps. L'invention concerne également des méthodes thérapeutiques permettant d'utiliser ces anticorps et parties de liaison avec l'antigène de ces anticorps pour réduire les niveaux de cholestérol LDL et/ou pour le traitement et/ou la prévention de maladies cardiovasculaires, y compris le traitement de l'hypercholestérolémie.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)