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1. WO2010029174 - METHOD FOR CLASSIFYING A CANCER PATIENT AS RESPONDER OR NON-RESPONDER TO IMMUNOTHERAPY

Publication Number WO/2010/029174
Publication Date 18.03.2010
International Application No. PCT/EP2009/061888
International Filing Date 14.09.2009
IPC
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
C12Q 1/68 (2006.01)
CPC
C12Q 1/6886
C12Q 2600/106
C12Q 2600/158
G01N 2800/52
G01N 33/6842
Applicants
  • GLAXOSMITHKLINE BIOLOGICALS S.A. [BE/BE]; Rue de l'Institut 89 B-1330 Rixensart, BE (AllExceptUS)
  • DUPONT, Pierre, Raphael [BE/BE]; BE (UsOnly)
  • GAULIS, Swann, Romain, Jean-Thomas [FR/BE]; BE (UsOnly)
  • HELLEPUTTE, Thibault, Marc [BE/BE]; BE (UsOnly)
Inventors
  • DUPONT, Pierre, Raphael; BE
  • GAULIS, Swann, Romain, Jean-Thomas; BE
  • HELLEPUTTE, Thibault, Marc; BE
Agents
  • LOVATT, Victoria, Jayne; GB
Priority Data
0816867.615.09.2008GB
61/192,04215.09.2008US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR CLASSIFYING A CANCER PATIENT AS RESPONDER OR NON-RESPONDER TO IMMUNOTHERAPY
(FR) MÉTHODE
Abstract
(EN)
Gene expression profiles, microarrays comprising nucleic acid sequences representing gene expression profiles, and new diagnostic kits and methods are provided. The kits and methods relate to the treatment of specific populations of, for example, cancer patients, as characterised by their gene expression profile, suffering from MAGE expressing tumours. A 33 gene expression signature identifies melanoma patients responding to treatment with MAGE-A3 ASCI.
(FR)
L'invention porte sur des profils d'expression génique, des microréseaux comprenant des séquences d'acides nucléiques représentant des profils d'expression génique, et sur de nouveaux kits de diagnostic ainsi que sur des méthodes. Les kits et procédés portent sur le traitement de populations spécifiques, par exemple, de patients cancéreux, tels que caractérisés par leur profil d'expression génique, souffrant de tumeurs exprimant MAGE.
Also published as
Latest bibliographic data on file with the International Bureau