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1. (WO2010028981) NEW BENZIMIDAZOLE DERIVATIVES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/028981    International Application No.:    PCT/EP2009/061252
Publication Date: 18.03.2010 International Filing Date: 01.09.2009
Chapter 2 Demand Filed:    27.04.2010    
IPC:
C07D 235/18 (2006.01), A61K 31/31 (2006.01), A61K 31/41 (2006.01), A61K 31/4184 (2006.01), A61K 31/437 (2006.01), A61K 31/4439 (2006.01), A61K 31/444 (2006.01), A61P 19/00 (2006.01), A61P 21/00 (2006.01), A61P 3/00 (2006.01), C07D 401/04 (2006.01), C07D 401/12 (2006.01), C07D 401/14 (2006.01), C07D 403/12 (2006.01), C07D 495/04 (2006.01)
Applicants: F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel (CH) (For All Designated States Except US).
BENSON, Gregory Martin [GB/CH]; (CH) (For US Only).
BLEICHER, Konrad [DE/DE]; (DE) (For US Only).
FENG, Song [CN/CN]; (CN) (For US Only).
GRETHER, Uwe [DE/DE]; (DE) (For US Only).
KUHN, Bernd [DE/CH]; (CH) (For US Only).
MARTIN, Rainer E. [AT/CH]; (CH) (For US Only).
PLANCHER, Jean-Marc [FR/FR]; (FR) (For US Only).
RICHTER, Hans [DE/DE]; (DE) (For US Only).
TAYLOR, Sven [FR/FR]; (FR) (For US Only)
Inventors: BENSON, Gregory Martin; (CH).
BLEICHER, Konrad; (DE).
FENG, Song; (CN).
GRETHER, Uwe; (DE).
KUHN, Bernd; (CH).
MARTIN, Rainer E.; (CH).
PLANCHER, Jean-Marc; (FR).
RICHTER, Hans; (DE).
TAYLOR, Sven; (FR)
Agent: WASCHBUESCH, Klaus; Grenzacherstrasse 124 CH-4070 Basel (CH)
Priority Data:
08164184.7 11.09.2008 EP
Title (EN) NEW BENZIMIDAZOLE DERIVATIVES
(FR) NOUVEAUX DÉRIVÉS DE BENZIMIDAZOLE
Abstract: front page image
(EN)The invention is concerned with novel benzimidazole derivatives of Formula (I) wherein A, n and R1 to R7 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds act on Farnesyl X receptor (FXR) and against cholesterol and lipid illnesses, diabetes, obesity, psoriasis, cancer, osteoporosis, Parkinson's and Alzheimer's disease.
(FR)L'invention porte sur de nouveaux dérivés de benzimidazole représentés par la Formule (I), dans laquelle A, n et R1 à R7 sont tels que définis dans la description et dans les revendications, ainsi que sur des sels et esters physiologiquement acceptables de ceux-ci. Ces composés agissent sur le récepteur Farnésoïde X (FXR) et contre des maladies liées au cholestérol et aux lipides, le diabète, l'obésité, le psoriasis, le cancer, l'ostéoporose, la maladie de Parkinson et la maladie d'Alzheimer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)