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Machine translation
1. (WO2010028347) CONTINUOUS DIRECTED EVOLUTION OF PROTEINS AND NUCLEIC ACIDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/028347    International Application No.:    PCT/US2009/056194
Publication Date: 11.03.2010 International Filing Date: 08.09.2009
IPC:
C12N 15/10 (2006.01), C12N 1/21 (2006.01), C12N 15/63 (2006.01)
Applicants: PRESIDENT & FELLOWS OF HARVARD COLLEGE [US/US]; 17 Quincy Street Cambridge, MA 02138 (US) (For All Designated States Except US).
LIU, David, R. [US/US]; (US) (For US Only).
ESVELT, Kevin, M. [US/US]; (US) (For US Only)
Inventors: LIU, David, R.; (US).
ESVELT, Kevin, M.; (US)
Agent: BAKER, C., Hunter; Wolf, Greenfield & Sacks, P.C. Federal Reserve Plaza 600 Atlantic Avenue Boston, MA 02210-2206 (US)
Priority Data:
61/094,666 05.09.2008 US
Title (EN) CONTINUOUS DIRECTED EVOLUTION OF PROTEINS AND NUCLEIC ACIDS
(FR) EVOLUTION DIRIGÉE CONTINUE DE PROTÉINES ET D'ACIDES NUCLÉIQUES
Abstract: front page image
(EN)The present invention discloses generalizable methods of evolving nucleic acids and proteins utilizing continuous directed evolution. The invention discloses methods of passing a nucleic acid from cell to cell in a desired function-dependent manner. The linkage of the desired function and passage of the nucleic acid from cell to cell allows for continuous selection and mutation of the nucleic acid.
(FR)La présente invention concerne des procédés généralisables pour faire évoluer des acides nucléiques et des protéines au moyen d'une évolution dirigée continue. L'invention concerne des procédés de passage d'un acide nucléique d'une cellule à une autre d'une manière dépendant d'une fonction désirée. La liaison de la fonction désirée et du passage de l'acide nucléique d'une cellule à une autre permet la sélection et la mutation continues de l'acide nucléique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)