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1. (WO2010028306) ANTIBODIES WITH MANNOSE BINDING LECTIN EFFECTOR FUNCTION FOR INHIBITING PATHOLOGIC INFLAMMATORY CONDITIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/028306    International Application No.:    PCT/US2009/056125
Publication Date: 11.03.2010 International Filing Date: 04.09.2009
IPC:
C07K 16/18 (2006.01), A61K 39/395 (2006.01), A61P 31/00 (2006.01)
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA OFFICE OF THE PRESIDENT [US/US]; 1111 Franklin Street, 5th Floor Oakland, CA 94607-5200 (US) (For All Designated States Except US).
SILVERMAN, Gregg, J. [US/US]; (US) (For US Only)
Inventors: SILVERMAN, Gregg, J.; (US)
Agent: ADRIANO, Sarah, B.; Mandel & Adriano 572 East Green Street, Suite 203 Pasadena, CA 91101 (US)
Priority Data:
61/191,067 05.09.2008 US
Title (EN) ANTIBODIES WITH MANNOSE BINDING LECTIN EFFECTOR FUNCTION FOR INHIBITING PATHOLOGIC INFLAMMATORY CONDITIONS
(FR) ANTICORPS POSSÉDANT UNE FONCTION D’EFFECTEUR DE LA LECTINE LIANT LE MANNOSE POUR L’INHIBITION D’ÉTATS INFLAMMATOIRES PATHOLOGIQUES
Abstract: front page image
(EN)The invention provides compositions comprising monoclonal antibodies which have variable regions that bind an antigen exposed on dead or dying cells and have constant region sequence that contains at least one site which is glycosylated. The antibodies have sufficient type and number of glycans that are ligand for mannose binding lectin (MBL), Administration of the antibodies to individuals suffering from a pathological inflammatory condition treats or inhibits the inflammation via recruitment of MBL.
(FR)La présente invention a pour objet des compositions comprenant des anticorps monoclonaux qui ont des régions variables qui lient un antigène exposé sur des cellules mortes ou mourantes et ont une séquence de régions constantes qui contient au moins un site qui est glycosylé. Les anticorps ont un type et un nombre suffisants de glycanes qui sont des ligands pour la lectine liant le mannose (MBL). L’administration des anticorps à des individus souffrant d’un état inflammatoire pathologique traite ou inhibe l’inflammation par l’intermédiaire du recrutement de la MBL.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)