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1. (WO2010028232) PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF 8-[{1-(3,5-BIS-(TRIFLUOROMETHYL)PHENYL)-ETHOXY}-METHYL]-8-PHENYL-1,7-DIAZA-SPIRO[4.5]DECAN-2-ONE COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/028232    International Application No.:    PCT/US2009/056020
Publication Date: 11.03.2010 International Filing Date: 04.09.2009
IPC:
C07D 207/26 (2006.01), C07D 471/10 (2006.01), C07D 498/04 (2006.01)
Applicants: OPKO HEALTH, INC. [US/US]; 4400 Biscayne Blvd. Suite 1180 Miami, Florida 33137 (US) (For All Designated States Except US).
WU, George, G. [US/US]; (US) (For US Only).
WERNE, Gerald [DE/DE]; (DE) (For US Only).
FU, Xiaoyong [US/US]; (US) (For US Only).
ORR, Robert, K. [US/US]; (US) (For US Only).
CHEN, Frank, Xing [US/US]; (US) (For US Only).
CUI, Jian [CN/US]; (US) (For US Only).
SPRAGUE, Victoria, M. [US/US]; (US) (For US Only).
ZHANG, Fucheng [CN/US]; (US) (For US Only).
XIE, Ji [CN/US]; (US) (For US Only).
ZENG, Liansheng [CN/US]; (US) (For US Only).
CASTELLANOS, Louis, Peter [US/US]; (US) (For US Only).
CHEN, Yuyin [CN/US]; (US) (For US Only).
POIRIER, Marc [CA/US]; (US) (For US Only).
MERGELSBERG, Ingrid [DE/US]; (US) (For US Only)
Inventors: WU, George, G.; (US).
WERNE, Gerald; (DE).
FU, Xiaoyong; (US).
ORR, Robert, K.; (US).
CHEN, Frank, Xing; (US).
CUI, Jian; (US).
SPRAGUE, Victoria, M.; (US).
ZHANG, Fucheng; (US).
XIE, Ji; (US).
ZENG, Liansheng; (US).
CASTELLANOS, Louis, Peter; (US).
CHEN, Yuyin; (US).
POIRIER, Marc; (US).
MERGELSBERG, Ingrid; (US)
Agent: JARRELL, Brenda Herschbach; Choate, Hall & Stewart LLP Two International Place Boston, Massachusetts 02110 (US)
Priority Data:
61/094,474 05.09.2008 US
Title (EN) PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF 8-[{1-(3,5-BIS-(TRIFLUOROMETHYL)PHENYL)-ETHOXY}-METHYL]-8-PHENYL-1,7-DIAZA-SPIRO[4.5]DECAN-2-ONE COMPOUNDS
(FR) PROCÉDÉ ET INTERMÉDIAIRES POUR LA SYNTHÈSE DE COMPOSÉS DE 8-[{1-(3,5-BIS(TRIFLUOROMÉTHYL)PHÉNYL)ÉTHOXY}MÉTHYL]-8-PHÉNYL-1,7-DIAZA-SPIRO[4.5]DÉCAN-2-ONE
Abstract: front page image
(EN)This application discloses a novel process to synthesize 8-[{1-(3,5-Bis- (trifluoromethyl)phenyl)-ethoxy}-nnethyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations intermediates useful in said process, and processes for preparing said intermediates; also disclosed is a process for removal of metals from N-heterocyclic carbine metal complexes. IM=102123
(FR)L’invention se rapporte à un nouveau procédé pour effectuer la synthèse de composés de 8-[{1-(3,5-bis(trifluorométhyl)phényl)éthoxy}méthyl]-8-phényl-1,7-diaza-spiro[4.5]décan-2-one qui peut être utilisé par exemple en tant que composés inhibiteurs de NK-1 dans des intermédiaires pour préparations pharmaceutiques utiles dans ledit procédé et l’invention se rapporte également aux procédés de préparation desdits intermédiaires. L’invention se rapporte enfin à un procédé pour éliminer les métaux de complexes métalliques carbènes N-hétérocycliques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)