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Machine translation
1. (WO2010028019) DIRECT REPROGRAMMING OF SOMATIC CELLS USING NON-INTEGRATING VECTORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/028019    International Application No.:    PCT/US2009/055698
Publication Date: 11.03.2010 International Filing Date: 02.09.2009
IPC:
C12N 5/074 (2010.01), C12N 5/10 (2006.01), C12N 15/861 (2006.01)
Applicants: THE GENERAL HOSPITAL CORPORATION [US/US]; 55 Fruit Street Boston, Massachusetts 02114 (US) (For All Designated States Except US).
PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US/US]; 17 Quincy Street Cambridge, Massachusetts 02138 (US) (For All Designated States Except US).
HOCHEDLINGER, Konrad [AT/US]; (US) (For US Only).
STADTFELD, Matthias [DE/US]; (US) (For US Only).
MAHERALI, Nimet [CA/US]; (US) (For US Only)
Inventors: HOCHEDLINGER, Konrad; (US).
STADTFELD, Matthias; (US).
MAHERALI, Nimet; (US)
Agent: RESNICK, David; (US)
Priority Data:
61/093,850 03.09.2008 US
Title (EN) DIRECT REPROGRAMMING OF SOMATIC CELLS USING NON-INTEGRATING VECTORS
(FR) REPROGRAMMATION DIRECTE DE CELLULES SOMATIQUES À L'AIDE DE VECTEURS NON INTÉGRANTS
Abstract: front page image
(EN)Provided herein are methods for producing induced pluripotent stem cells with the use of a non-integrating vector. Reprogramming of cells using a non-integrating vector (e.g., adenoviral vector) permits the generation of induced pluripotent stem cells that do not contain leftover viral genes that can be reactivated in the cell. This type of transient reprogramming is further contemplated for production of induced pluripotent stem cells for delivery to an individual.
(FR)L'invention porte sur des procédés de production de cellules souches pluripotentes induites avec l'utilisation d'un vecteur non intégrant. La reprogrammation de cellules à l'aide d'un vecteur non intégrant (par exemple, un vecteur adénoviral) permet la génération de cellules souches pluripotentes induites qui ne contiennent pas de gènes viraux restants qui peuvent être réactivés dans la cellule. Ce type de reprogrammation transitoire est en outre envisagé pour la production de cellules souches pluripotentes induites pour une administration à un individu.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)