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1. (WO2010027965) COMPOSITIONS AND METHODS FOR DECREASING TYPE III DEIODINASE ACTIVITY TO MODULATE ADIPOSITY AND BLOOD GLUCOSE LEVELS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/027965    International Application No.:    PCT/US2009/055597
Publication Date: 11.03.2010 International Filing Date: 01.09.2009
IPC:
A61K 39/395 (2006.01), A01N 43/04 (2006.01)
Applicants: TRUSTEES OF DARTMOUTH COLLEGE [US/US]; Technology Transfer Office 11 Rope Ferry Road Hanover, NH 03755-1404 (US) (For All Designated States Except US).
ST. GERMAIN, Donald, L. [US/US]; (US) (For US Only).
HERNANDEZ, Arturo [ES/US]; (US) (For US Only)
Inventors: ST. GERMAIN, Donald, L.; (US).
HERNANDEZ, Arturo; (US)
Agent: LICATA, Jane Massey; Licata & Tyrrell P.C. 66 E. Main Street Marlton, NJ 08053 (US)
Priority Data:
61/093,542 02.09.2008 US
Title (EN) COMPOSITIONS AND METHODS FOR DECREASING TYPE III DEIODINASE ACTIVITY TO MODULATE ADIPOSITY AND BLOOD GLUCOSE LEVELS
(FR) COMPOSITIONS ET PROCÉDÉS POUR DIMINUER L'ACTIVITÉ DE DÉSIODASE DE TYPE III POUR MODULER L'ADIPOSITÉ ET LES NIVEAUX DE GLYCÉMIE
Abstract: front page image
(EN)The present invention features methods for decreasing fat mass, increasing energy expenditure, increasing resistance to obesity, and lowering blood glucose levels in a subject with an agent that inhibits the expression or activity of type III deiodinase. In this regard, agents of the invention are useful in treating diabetes and obesity.
(FR)La présente invention concerne des procédés pour diminuer la masse graisseuse, pour augmenter la dépense énergétique et la résistance à l'obésité, et pour abaisser les niveaux de glycémie chez un sujet à l'aide d'un agent qui empêche l'expression ou l'activité de désiodase de type III. À cet égard, les agents de l'invention sont utiles dans le traitement du diabète et de l'obésité.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)