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1. (WO2010027594) CINNAMIC ACID-BASED OLIGOMERS AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/027594    International Application No.:    PCT/US2009/052684
Publication Date: 11.03.2010 International Filing Date: 04.08.2009
IPC:
C07C 69/736 (2006.01), C07C 69/618 (2006.01), C07C 305/24 (2006.01), C07D 407/04 (2006.01), C07D 307/77 (2006.01), A61K 31/192 (2006.01), A61K 31/185 (2006.01), A61K 31/343 (2006.01), A61P 29/00 (2006.01), A61P 11/00 (2006.01)
Applicants: VIRGINIA COMMONWEALTH UNIVERSITY [US/US]; 800 E. Leigh Street Richmond, VA 23219 (US) (For All Designated States Except US).
DESAL, Umesh, R. [US/US]; (US) (For US Only).
HENRY, Brian, L. [US/US]; (US) (For US Only).
LIANG, Aiye [CN/US]; (US) (For US Only).
THAKKAR, Jay [IN/US]; (US) (For US Only).
MANGRUM, John, B. [US/US]; (US) (For US Only).
FILHO, Ivo, Torres [US/US]; (US) (For US Only).
SPIESS, Bruce, D. [US/US]; (US) (For US Only).
SAKAGAMI, Masahiro [JP/US]; (US) (For US Only).
SALUJA, Bhawana [IN/US]; (US) (For US Only)
Inventors: DESAL, Umesh, R.; (US).
HENRY, Brian, L.; (US).
LIANG, Aiye; (US).
THAKKAR, Jay; (US).
MANGRUM, John, B.; (US).
FILHO, Ivo, Torres; (US).
SPIESS, Bruce, D.; (US).
SAKAGAMI, Masahiro; (US).
SALUJA, Bhawana; (US)
Agent: WHITHAM, Michael, E.; Whitham, Curtis, Christofferson & Cook, PC 11491 Sunset Hills Road, Suite 340 Reston, VA 20190 (US)
Priority Data:
61/091,487 25.08.2008 US
61/085,916 04.08.2008 US
Title (EN) CINNAMIC ACID-BASED OLIGOMERS AND USES THEREOF
(FR) OLIGOMÈRES À BASE D’ACIDE CINNAMIQUE ET LEURS UTILISATIONS
Abstract: front page image
(EN)Cinnamic acid-based oligomers and therapeutic uses thereof are provided. The oligomers are used as anti-inflammation agents, inhibitors of elastase and anti-oxidants, and in some cases (e.g. the treatment of lung disorders such as lung cancer) all three activities are simultaneously beneficial. Subsets of the oligomers (e.g. β-O4 and β-5 trimers and tetramers) are used as anticoagulants.
(FR)L’invention concerne des oligomères à base d’acide cinnamique et leurs utilisations thérapeutiques. Les oligomères sont utilisés comme anti-inflammatoires, inhibiteurs de l’élastase et antioxydants. Dans certains cas (par ex., le traitement de troubles pulmonaires comme le cancer du poumon), les trois activités sont simultanément bénéfiques. Des sous-ensembles des oligomères (par ex., de trimères et des tétramères β-O4 et β-5) sont utilisés comme anticoagulants.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)