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1. (WO2010027431) SUBSTITUTED TRICYCLIC ACID DERIVATIVES AS S1P1 RECEPTOR AGONISTS USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/027431    International Application No.:    PCT/US2009/004851
Publication Date: 11.03.2010 International Filing Date: 26.08.2009
Chapter 2 Demand Filed:    24.06.2010    
IPC:
C07D 487/04 (2006.01), A61K 31/407 (2006.01), A61K 31/437 (2006.01), A61P 29/00 (2006.01), A61P 31/12 (2006.01), A61P 37/00 (2006.01)
Applicants: ARENA PHARMACEUTICALS, INC. [US/US]; 6166 Nancy Ridge Drive San Diego, California 92121-3223 (US) (For All Designated States Except US).
JONES, Robert, M. [GB/US]; (US) (For US Only).
BUZARD, Daniel, J. [US/US]; (US) (For US Only).
KAWASAKI, Andrew, M. [US/US]; (US) (For US Only).
KIM, Sun Hee [KR/US]; (US) (For US Only).
THORESEN, Lars [US/US]; (US) (For US Only).
LEHMANN, Juerg [CH/US]; (US) (For US Only).
ZHU, Xiuwen [CN/US]; (US) (For US Only)
Inventors: JONES, Robert, M.; (US).
BUZARD, Daniel, J.; (US).
KAWASAKI, Andrew, M.; (US).
KIM, Sun Hee; (US).
THORESEN, Lars; (US).
LEHMANN, Juerg; (US).
ZHU, Xiuwen; (US)
Agent: GODDARD, Christine, A.; Fish & Richardson P.C. P.O. Box 1022 Minneapolis, MN 55440-1022 (US).
WYTENBURG, Wilhelmus, J.; Mewburn Ellis LLP 33 Gutter Lane London EC2V 8AS (GB)
Priority Data:
61/190,311 27.08.2008 US
61/269,519 24.06.2009 US
Title (EN) SUBSTITUTED TRICYCLIC ACID DERIVATIVES AS S1P1 RECEPTOR AGONISTS USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS
(FR) DERIVES D'ACIDES TRICYCLIQUES SUBSTITUES, UTILES DANS LE TRAITEMENT DES TROUBLES AUTO-IMMUNS ET INFLAMMATOIRES
Abstract: front page image
(EN)The present invention relates to certain substituted tricyclic acid derivatives of Formula (I) and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the S1P1 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of S1P1-associated disorders, for example, psoriasis, rheumatoid arthritis, Crohn's disease, transplant rejection, multiple sclerosis, systemic lupus erythematosus, ulcerative colitis, type I diabetes, acne, myocardial ischemia-reperfusion injury injury, hypertensive nephropathy, glomerulosclerosis, gastritis, polymyositis, thyroiditis, vitiligo, hepatitis, biliary cirrhosis, microbial infections and associated diseases, viral infections and associated diseases, diseases and disorders mediated by lymphocytes, auto immune diseases, inflammatory diseases, and cancer.
(FR)L'invention concerne certains dérivés d'acides tricycliques substitués de Formule (I) et de sels pharmaceutiquement acceptables de ceux-ci, qui présentent des propriétés pharmacologiques utiles, par exemple en tant qu'agonistes du récepteur S1P1. L'invention concerne également des compositions pharmaceutiques contenant des composés selon l'invention, ainsi que des méthodes d'utilisation de ces composés et compositions dans le traitement des troubles liés à S1P1, par exemple le psoriasis, la polyarthrite rhumatoïde, la maladie de Crohn, le rejet de greffe, la sclérose en plaques, le lupus érythémateux systémique, la colite ulcéreuse, le diabète de type I, l'acné, la lésion d'ischémie-reperfusion myocardique, la néphropathie hypertensive, la glomérulosclérose, la gastrite, la polymyosite, la thyroïdite, le vitiligo, l'hépatite, la cirrhose biliaire, les infections microbiennes et maladies connexes, les infections virales et maladies connexes, les maladies et troubles induits par les lymphocytes, les maladies auto-immunes, les maladies inflammatoires et le cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)