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1. (WO2010027428) PLATINUM ( IV) COMPLEXES FOR USE IN DUAL MODE PHARMACEUTICAL THERAPY
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/027428 International Application No.: PCT/US2009/004846
Publication Date: 11.03.2010 International Filing Date: 26.08.2009
IPC:
A61K 31/19 (2006.01) ,A61K 33/24 (2006.01) ,A61K 45/06 (2006.01) ,A61P 35/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33
Medicinal preparations containing inorganic active ingredients
24
Heavy metals; Compounds thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
LIPPARD, Stephen, J. [US/US]; US (UsOnly)
DHAR, Shanta [IN/US]; US (UsOnly)
MASSACHUSETTS INSTITUTE OF TECHNOLOGY [US/US]; 77 Massachusetts Avenue Cambridge, MA 02139, US (AllExceptUS)
Inventors:
LIPPARD, Stephen, J.; US
DHAR, Shanta; US
Agent:
OYER, Timothy, J.; US
Priority Data:
61/091,97726.08.2008US
61/196,41917.10.2008US
Title (EN) PLATINUM ( IV) COMPLEXES FOR USE IN DUAL MODE PHARMACEUTICAL THERAPY
(FR) COMPLEXES DE PLATINE (IV) POUR UTILISATION DANS UNE THÉRAPIE PHARMACEUTIQUE EN MODE DOUBLE
Abstract:
(EN) The present invention provides compositions, preparations, formulations, kits, and methods useful for treating subjects in need of therapeutic protocol, including subjects having cancer or at risk of developing cancer. Some embodiments of the invention may comprise a composition comprising a first component comprising a precursor to a therapeutically active platinum agent and a precursor to a second therapeutically active agent. The therapeutically active platinum agent and the second therapeutically active agent may dissociate from each other, thereby forming a first therapeutically active platinum agent and a second therapeutically active agent. The second therapeutically active gent may affect a cellular pathway of a cancer cell and may be substantially inactive towards non-cancerous cells.
(FR) La présente invention concerne des compositions, des préparations, des formulations, des trousses, et des procédés utiles pour traiter des sujets nécessitant un protocole thérapeutique, comprenant des sujets ayant un cancer ou présentant un risque de développer un cancer. Certains modes de réalisation de l’invention peuvent comprendre une composition comprenant un premier composant comprenant un précurseur d’un agent de platine thérapeutiquement actif et un précurseur d’un deuxième agent thérapeutiquement actif. L’agent de platine thérapeutiquement actif et le deuxième agent thérapeutiquement actif peuvent se dissocier l’un de l’autre, de manière à former un premier agent de platine thérapeutiquement actif et un deuxième agent thérapeutiquement actif. Le deuxième agent thérapeutiquement actif peut affecter une voie cellulaire d’une cellule cancéreuse et peut être sensiblement inactif sur des cellules non cancéreuses.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)