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1. (WO2010026735) AMYLOID β AGGREGATION PROMOTION PEPTIDE AND APPLICATION THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/026735    International Application No.:    PCT/JP2009/004275
Publication Date: 11.03.2010 International Filing Date: 01.09.2009
Chapter 2 Demand Filed:    25.05.2010    
IPC:
C07K 7/06 (2006.01), A61K 38/00 (2006.01), A61P 25/28 (2006.01)
Applicants: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY [JP/JP]; 1, Furo-cho, Chikusa-ku, Nagoya-shi, Aichi 4648601 (JP) (For All Designated States Except US).
HONDA, Hiroyuki [JP/JP]; (JP) (For US Only).
OKOCHI, Mina [JP/JP]; (JP) (For US Only).
GOTO, Hiroaki [JP/JP]; (JP) (For US Only).
KAGA, Chiaki [JP/JP]; (JP) (For US Only).
SAWADA, Makoto [JP/JP]; (JP) (For US Only).
MIZOGUCHI, Hiroyuki [JP/JP]; (JP) (For US Only)
Inventors: HONDA, Hiroyuki; (JP).
OKOCHI, Mina; (JP).
GOTO, Hiroaki; (JP).
KAGA, Chiaki; (JP).
SAWADA, Makoto; (JP).
MIZOGUCHI, Hiroyuki; (JP)
Agent: HAGINO, Mikiharu; 1-1, Technoplaza, Kakamigahara-shi, Gifu 5090109 (JP)
Priority Data:
2008-228974 05.09.2008 JP
Title (EN) AMYLOID β AGGREGATION PROMOTION PEPTIDE AND APPLICATION THEREOF
(FR) PEPTIDE FAVORISANT L'AGRÉGATION D'AMYLOÏDE β
(JA) アミロイドβ凝集促進ペプチド及びその用途
Abstract: front page image
(EN)Disclosed is a peptide that promotes Aβ aggregation. An amyloid β aggregation promotion peptide is provided that contains an amino acid sequence expressed as Xaa1-Xaa2-Xaa3-Xaa4-Xaa5 (sequence number 1) (wherein, Xaa1 is lysine or arginine, Xaa2 is leucine or isoleucine, Xaa3 is valine, isoleucine, leucine, lysine, phenylalanine, or tyrosine, Xaa4 is phenylalanine, isoleucine, leucine, lysine, or valine, and Xaa5 is phenylalanine, alanine, arginine, asparagine, cysteine, glycine, isoleucine, leucine, lysine, serine, tryptophan, tyrosine, or valine, and is not Lys-Leu-Val-Phe-Phe (sequence number 7).
(FR)L'invention concerne un peptide qui favorise l'agrégation Aβ. L'invention concerne un peptide favorisant d l'agrégation d'amyloïde β qui contient une séquence d'acide aminé exprimé en tant que Xaa1-Xaa2-Xaa3-Xaa4-Xaa5 (séquence no1) (dans laquelle Xaa1 représente lysine ou arginine, Xaa2 leucine ou isoleucine, Xaa3 valine, isoleucine, leucine, lysine, phénylalanine, ou tyrosine, Xaa4 phénylalanine, alanine, arginine, asparagine, cystéine, glycine, isoleucine, leucine, lysine, sérine, tryptophane, tyrosine, ou valine, et ne représente pas Lys-Leu-Val-Phe-Phe (séquence no7).
(JA) Aβの凝集を促進するペプチドを提供することを課題とする。Xaa1-Xaa2-Xaa3-Xaa4-Xaa5(配列番号1)で表されるアミノ酸配列(但し、Xaa1はリジン又はアルギニン、Xaa2はロイシン又はイソロイシン、Xaa3はバリン、イソロイシン、ロイシン、リジン、フェニルアラニン又はチロシン、Xaa4はフェニルアラニン、イソロイシン、ロイシン、リジン又はバリン、Xaa5はフェニルアラニン、アラニン、アルギニン、アスパラギン、システイン、グリシン、イソロイシン、ロイシン、リジン、セリン、トリプトファン、チロシン又はバリンであり、且つLys-Leu-Val-Phe-Phe(配列番号7)ではない)を含む、アミロイドβ凝集促進ペプチドが提供される。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)