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1. (WO2010026176) 1,4 -DIAZA- BICYCLO [3.2.2]N0NYL PYRIMIDINE DERIVATIVES AS NICOTINIC AND MONOAMINE RECEPTOR MODULATORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/026176    International Application No.:    PCT/EP2009/061374
Publication Date: 11.03.2010 International Filing Date: 03.09.2009
IPC:
C07D 471/08 (2006.01), A61K 31/551 (2006.01), A61P 25/16 (2006.01)
Applicants: NEUROSEARCH A/S [DK/DK]; Pederstrupvej 93 DK-2750 Ballerup (DK) (For All Designated States Except US).
PETERS, Dan [SE/DK]; (DK) (For US Only).
TIMMERMANN, Daniel, B. [DK/DK]; (DK) (For US Only).
OLSEN, Gunnar, M. [DK/DK]; (DK) (For US Only).
NIELSEN, Elsebet, Østergaard [DK/DK]; (DK) (For US Only).
AHRING, Philip, K. [DK/DK]; (DK) (For US Only).
DYHRING, Tino [DK/DK]; (DK) (For US Only).
CHRISTENSEN, Jeppe, Kejser [DK/DK]; (DK) (For US Only)
Inventors: PETERS, Dan; (DK).
TIMMERMANN, Daniel, B.; (DK).
OLSEN, Gunnar, M.; (DK).
NIELSEN, Elsebet, Østergaard; (DK).
AHRING, Philip, K.; (DK).
DYHRING, Tino; (DK).
CHRISTENSEN, Jeppe, Kejser; (DK)
Common
Representative:
NEUROSEARCH A/S; Patent Department Pederstrupvej 93 DK-2750 Ballerup (DK)
Priority Data:
PA 2008 01242 05.09.2008 DK
61/094,559 05.09.2008 US
Title (EN) 1,4 -DIAZA- BICYCLO [3.2.2]N0NYL PYRIMIDINE DERIVATIVES AS NICOTINIC AND MONOAMINE RECEPTOR MODULATORS
(FR) DÉRIVÉS DE 1,4-DIAZA-BICYCLO[3.2.2]NONYL PYRIMIDINE UTILISÉS COMME MODULATEURS DES RÉCEPTEURS ET TRANSPORTEURS DE MONOAMINE ET NICOTINIQUES
Abstract: front page image
(EN)This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
(FR)La présente invention concerne de nouveaux dérivés de 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine et leur utilisation dans la préparation de compositions pharmaceutiques. Il a été observé que les composés de l'invention sont des ligands cholinergiques au niveau des récepteurs nicotiniques de l'acétylcholine et des modulateurs des récepteurs et transporteurs de monoamine. En raison de leur profil pharmacologique, les composés de l'invention peuvent être utiles pour le traitement de maladies ou de troubles aussi divers que ceux associés au système cholinergique du système nerveux central (SNC) ou du système nerveux périphérique (SNP), les maladies ou troubles associés à la contraction des muscles lisses, les maladies ou troubles endocriniens, les maladies ou troubles associés à la neurodégénérescence, les maladies ou troubles associés à l'inflammation, la douleur et les symptômes de sevrage causés par l'arrêt de la consommation abusive de substances chimiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)