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1. (WO2010026134) TRIAZOLE DERIVATIVES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/026134    International Application No.:    PCT/EP2009/061262
Publication Date: 11.03.2010 International Filing Date: 01.09.2009
IPC:
C07D 401/04 (2006.01), C07D 407/14 (2006.01), A61K 31/4196 (2006.01), A61P 25/00 (2006.01)
Applicants: NEUROSEARCH A/S [DK/DK]; Patent Department Pederstrupvej 93 DK-2750 Ballerup (DK) (For All Designated States Except US).
DAHL, Bjarne, H. [DK/DK]; (DK) (For US Only).
OLSEN, Gunnar, M. [DK/DK]; (DK) (For US Only).
CHRISTENSEN, Jeppe, Kejser [DK/DK]; (DK) (For US Only).
PETERS, Dan [SE/DK]; (DK) (For US Only)
Inventors: DAHL, Bjarne, H.; (DK).
OLSEN, Gunnar, M.; (DK).
CHRISTENSEN, Jeppe, Kejser; (DK).
PETERS, Dan; (DK)
Common
Representative:
NEUROSEARCH A/S; Patent Department Pederstrupvej 93 DK-2750 Ballerup (DK)
Priority Data:
PA 2008 01220 02.09.2008 DK
61/094,136 04.09.2008 US
Title (EN) TRIAZOLE DERIVATIVES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS
(FR) DÉRIVÉS DE TRIAZOLE ET LEUR UTILISATION EN TANT QUE MODULATEURS DE RÉCEPTEUR NICOTINIQUE D’ACÉTYLCHOLINE
Abstract: front page image
(EN)This invention relates to novel triazole derivatives, which are found to be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
(FR)La présente invention concerne de nouveaux dérivés de triazole, qui ont été découverts comme étant des modulateurs des récepteurs nicotiniques d’acétylcholine. En raison de leur profil pharmacologique, les composés de l’invention peuvent être utiles pour le traitement de maladies ou troubles aussi divers que ceux liés au système cholinergique du système nerveux central (SNC), du système nerveux périphérique (SNP), de maladies ou troubles liés à la contraction de muscle lisse, de maladies ou troubles endocriniens, de maladies ou troubles liés à la neurodégénérescence, de maladies ou troubles liés à l’inflammation, la douleur, et les symptômes de sevrage causés par l’arrêt de l’abus de substances chimiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)