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Pub. No.:    WO/2010/025906    International Application No.:    PCT/EP2009/006359
Publication Date: 11.03.2010 International Filing Date: 02.09.2009
C07D 401/12 (2006.01), C07D 471/04 (2006.01), A61K 31/33 (2006.01), A61P 31/00 (2006.01)
Applicants: MERLION PHARMACEUTICALS PTE LTD [SG/SG]; 1 Science Park Road The Capricorn #05-01 Singapore Science Park II Singapore 117528 (SG) (For All Designated States Except US).
LABISCHINSKI, Harald [DE/DE]; (DE) (For US Only).
CHERIAN, Joseph [IN/SG]; (SG) (For US Only).
CALANASAN, Cleofe [PH/SG]; (SG) (For US Only).
BOYCE, Rustum S. [IN/US]; (US) (For US Only)
Inventors: LABISCHINSKI, Harald; (DE).
CHERIAN, Joseph; (SG).
CALANASAN, Cleofe; (SG).
BOYCE, Rustum S.; (US)
Agent: WEBSTER, Jeremy, Mark; Mewburn Ellis LLP 33 Gutter Lane London EC2V 8AS (GB)
Priority Data:
0815962.6 02.09.2008 GB
61/093,472 02.09.2008 US
Abstract: front page image
(EN)The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain antimicrobial compounds comprising pharmacophores based on or comprising benzyl pyrimidines and 4-quinolones or 4H-4-oxoquinolizines (for convenience, collectively referred to herein as "BP-4Q compounds"), which, inter alia, are antimicrobial, particularly antibacterial. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to provide an antimicrobial function, particularly an antibacterial function, and in the treatment of diseases and conditions that are mediated by microbes, particularly bacteria, that are ameliorated by the antimicrobial function, particularly an antibacterial function, including bacterial diseases, optionally in combination with another agent, for example, another antibacterial agent.
(FR)La présente invention a trait, d'une manière générale, au domaine des composés thérapeutiques et, plus précisément, à certains composés antimicrobiens qui comportent des pharmacophores à base de benzylpyrimidines et de 4-quinolones ou 4H-4-oxoquinolizines (pour plus de facilité, collectivement appelés ci-après « composés BP-4Q ») ou comportant ceux-ci, qui sont, entre autres, des antimicrobiens, en particulier des antibactériens. La présente invention a également trait à des compositions pharmaceutiques qui comportent de tels composés et à l'utilisation de tels composés et de telles compositions, à la fois in vitro et in vivo, pour fournir une fonction antimicrobienne, en particulier une fonction antibactérienne, et dans le traitement de maladies et d'états qui sont à médiation par des microbes, en particulier des bactéries, qui sont améliorés par la fonction antimicrobienne, en particulier la fonction antibactérienne, et qui comprennent des maladies bactériennes, facultativement en combinaison avec un autre agent, par exemple, un autre agent antibactérien.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)