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1. (WO2010025566) RNA MONOMERS CONTAINING O-ACETAL LEVULINYL ESTER GROUPS AND THEIR USE IN RNA MICROARRAYS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/025566    International Application No.:    PCT/CA2009/001244
Publication Date: 11.03.2010 International Filing Date: 04.09.2009
IPC:
C07H 19/04 (2006.01), C07H 19/067 (2006.01), C07H 19/167 (2006.01), C07H 21/02 (2006.01), C12Q 1/68 (2006.01), C40B 30/04 (2006.01), C40B 40/06 (2006.01), C40B 50/14 (2006.01)
Applicants: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY [CA/CA]; 845 Sherbrooke Street West Montreal , Québec H3A 2T5 (CA) (For All Designated States Except US).
WISCONSIN ALUMNI RESEARCH FOUNDATION [US/US]; 614 Walnut St. Madison, Wisconsin 53726 (US) (For All Designated States Except US).
DAMHA, Masad [CA/CA]; (CA) (For US Only).
LACKEY, Jeremy [CA/CA]; (CA) (For US Only).
MITRA, Debbie [CA/CA]; (CA) (For US Only).
WICKENS, Marvin [US/US]; (US) (For US Only).
CERRINA, Franco [US/US]; (US) (For US Only).
SOMOZA, Mark [US/AT]; (AT) (For US Only)
Inventors: DAMHA, Masad; (CA).
LACKEY, Jeremy; (CA).
MITRA, Debbie; (CA).
WICKENS, Marvin; (US).
CERRINA, Franco; (US).
SOMOZA, Mark; (AT)
Agent: OGILVY RENAULT LLP/S.E.N.C.R.L., s.r.l.; Suite 2500 1 Place Ville Marie Montreal , Québec H3B 1R1 (CA)
Priority Data:
61/094,525 05.09.2008 US
61/181,562 27.05.2009 US
Title (EN) RNA MONOMERS CONTAINING O-ACETAL LEVULINYL ESTER GROUPS AND THEIR USE IN RNA MICROARRAYS
(FR) MONOMÈRES D'ARN CONTENANT DES GROUPES D'ESTERS DE LÉVULINYLE O-ACÉTAL ET LEUR UTILISATION DANS DES MICRORÉSEAUX D'ARN
Abstract: front page image
(EN)The present invention is directed to RNA monomers comprising O-acetal levulinyl protecting groups at the 2' and/or the 5'-hydroxy functionalities of the ribose moiety. Said monomers may be incorporated into oligoribonucleotides or RNA polynucleotides. Furthermore, the invention is directed to methods for the synthesis of said RNA monomers, oligoribonucleotides and RNA polynucleotides, as well as methods for their deprotection and methods for the use of said compounds and compositions comprising said compounds. In particular, such compounds and compositons comprising them are used in methods for light-directed synthesis of RNA microarrays.
(FR)L'invention porte sur des monomères d'ARN comprenant des groupes de protection lévulinyle O-acétal au niveau de la ou des fonctions 2'-hydroxy et/ou 5'-hydroxy du groupement ribose. Ces monomères peuvent être incorporés dans des oligoribonucléotides ou dans des polynucléotides d'ARN. En outre, l'invention concerne des procédés pour synthétiser lesdits monomères d'ARN, lesdits oligoribonucléotides, et lesdits polynucléotides d'ARN, ainsi que des procédés de déprotection de ceux-ci et d'utilisation de tels composés et de compositions comprenant de tels composés. En particulier, lesdits composés et les compositions les comprenant sont utilisés dans des procédés pour une synthèse photodirigée de microréseaux d'ARN.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)