CA2009001224 TRIAZOLIUM AND IMIDAZOLIUM SALTS AND USES THEREOF

1. (WO2010025558) TRIAZOLIUM AND IMIDAZOLIUM SALTS AND USES THEREOF

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Latest bibliographic data on file with the International Bureau

Pub. No.:		WO/2010/025558		International Application No.:		PCT/CA2009/001224
Publication Date:		11.03.2010		International Filing Date:		04.09.2009

IPC:

C07D 249/08 (2006.01), A61K 31/4164 (2006.01), A61K 31/4196 (2006.01), A61P 33/02 (2006.01), C07D 233/56 (2006.01)

Applicants:

UNIVERSITY HEALTH NETWORK [CA/CA]; 101 College Street Heritage Building - MaRS Centre Suite 150 Toronto, Ontario M5G 1L7 (CA) (For All Designated States Except US).
CRANDALL, Ian, E. [CA/CA]; (CA) (For US Only).
SZAREK, Walter, A. [CA/CA]; (CA) (For US Only).
VLAHAKIS, Jason, Z. [CA/CA]; (CA) (For US Only)

Inventors:

CRANDALL, Ian, E.; (CA).
SZAREK, Walter, A.; (CA).
VLAHAKIS, Jason, Z.; (CA)

Agent:

BERESKIN & PARR LLP/S.E.N.C.R.L., s.r.l.; 40 King Street West 40th Floor Toronto, Ontario M5H 3Y2 (CA)

Priority Data:

61/094,536

05.09.2008

Title

(EN) TRIAZOLIUM AND IMIDAZOLIUM SALTS AND USES THEREOF
(FR) SELS DE TRIAZOLIUM ET D'IMIDAZOLIUM ET UTILISATIONS DE CEUX-CI EN TANT QU'ANTIPALUDÉENS

Abstract:

(EN)The present disclosure relates to certain new and known triazolium and/or imidazolium salts and to their therapeutic use, for example in methods of treating or preventing an infection by a Plasmodium or Babesia parasite in a subject in need thereof. The triazolium and imidazolium salts are compounds of the Formula (I) or (II): wherein R¹-R⁴, R^1'-R^3', R⁸-R¹¹, X, X', X", Y, Y' and Y" are as defined in the disclosure.
(FR)La présente invention concerne certains sels de triazolium et/ou d'imidazolium nouveaux et connus et leur utilisation thérapeutique, par exemple dans des procédés de traitement ou de prévention d'une infection par un parasite Plasmodium ou Babesia chez un sujet nécessitant ceux-ci. Les sels de triazolium et d'imidazolium sont des composés de formule (I) ou (II) : dans lesquelles R¹ à R⁴, R^1' à R^3', R⁸ à R¹¹, X, X', X", Y, Y' et Y" sont comme définis dans la description.

Designated States:

AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).

Publication Language:	English (EN)
Filing Language:	English (EN)

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