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Pub. No.:    WO/2010/025459    International Application No.:    PCT/US2009/055546
Publication Date: 04.03.2010 International Filing Date: 31.08.2009
A61K 31/4164 (2006.01), A61P 9/06 (2006.01)
Applicants: THE UAB RESEARCH FOUNDATION [US/US]; AB770 1530 3rd Avenue South Birmingham, Alabama 35294-0107 (US) (For All Designated States Except US).
WOLKOWICZ, Paul E. [US/US]; (US) (For US Only)
Inventors: WOLKOWICZ, Paul E.; (US)
Agent: PETERSON, Gregory, T.; Bradley Arant Boult Cummings LLP One Federal Place 1819 Fifth Avenue North Birmingham, Alabama 35203-2104 (US)
Priority Data:
61/093,261 29.08.2008 US
Abstract: front page image
(EN)It has been discovered that SKF-96365 prevents and reverses ectopic activity in myocyte cells, and that SKF-96365 is effective against all types of ectopic activity. Methods are provided using SKF-96365 and its derivatives to prevent and reverse electromechanical disorders of myocytes; these include methods of treatment and prevention of cardiac arrhythmias in human and animal subjects. These further include methods of preventing and reversing arrhythmias in cardiac muscles and hearts. These further include methods of preventing and reversing spontaneous mechanical activity in a myocyte. Pharmaceutical drugs for the treatment and prevention of cardiac arrhythmia are described, based on SKF-96365. Kits for employing the methods are also described.
(FR)Selon la présente invention, il a été découvert que SKF-96365 prévient et supprime l'activité ectopique dans les myocytes, et que SKF-96365 est efficace contre tous les types d'activité ectopique. L'invention concerne des méthodes utilisant SKF-96365 et ses dérivés pour prévenir et supprimer les troubles de l'activité électromécanique des myocytes, notamment des méthodes de traitement et de prévention des arythmies cardiaques chez des sujets humains et animaux. Ces méthodes comprennent en outre des méthodes permettant de prévenir et de supprimer les arythmies dans les muscles cardiaques et le cœur. Elles comprennent également des méthodes permettant de prévenir et de supprimer l'activité mécanique spontanée dans un myocyte. L'invention concerne également des médicaments pharmaceutiques à base de SKF-96365 destinés au traitement et à la prévention de l'arythmie cardiaque, ainsi que des trousses permettant d'employer lesdites méthodes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)