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Machine translation
1. (WO2010025303) DOSING AND MONITORING PATIENTS ON NITROGEN-SCAVENGING DRUGS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/025303    International Application No.:    PCT/US2009/055256
Publication Date: 04.03.2010 International Filing Date: 27.08.2009
IPC:
G01N 33/50 (2006.01)
Applicants: UCYCLYD PHARMA, INC. [US/US]; 7720 North Dobson Road Scottsdale, Arizona 85256 (US) (For All Designated States Except US).
SCHARSCHMIDT, Bruce [US/US]; (US) (For US Only)
Inventors: SCHARSCHMIDT, Bruce; (US)
Agent: SMITH, Michael, G.; Morrison & Foerster LLP 12531 High Bluff Drive, Suite 100 San Diego, CA 92130-2040 (US)
Priority Data:
61/093,234 29.08.2008 US
12/350,111 07.01.2009 US
PCT/US09/30362 07.01.2009 US
Title (EN) DOSING AND MONITORING PATIENTS ON NITROGEN-SCAVENGING DRUGS
(FR) DOSAGE ET SURVEILLANCE DE PATIENTS EN TRAITEMENT PAR DES MÉDICAMENTS DÉSACTIVANT L'AZOTE
Abstract: front page image
(EN)The invention provides a method for determining a dose and dosing schedule, and making dose adjustments of patients taking PBA prodrugs as nitrogen scavengers to treat nitrogen retention states, including ammonia accumulation disorders as well as chronic renal failure, by measuring urinary excretion of phenylacetylglutamine and/or total urinary nitrogen. The invention provides methods to select an appropriate dosage of a PBA prodrug based on the patient's dietary protein intake, or based on previous treatments administered to the patient. The methods are applicable to selecting or modifying a dosing regimen for a subject receiving an orally administered waste nitrogen scavenging drug, and to monitoring patients receiving such drugs.
(FR)L'invention concerne un procédé permettant de déterminer une dose et un programme de dosage, et d'effectuer des réglages de dosage pour des patients prenant des promédicaments PBA tels que des épurateurs d'azote pour traiter des états de rétention d'azote, y compris des troubles d'accumulation d'ammoniac, ainsi que l'insuffisance rénale chronique, au moyen de mesures d'excrétion urinaire de phénylacétylglutamine et/ou d'azote urinaire total. L'invention concerne des procédés permettant de sélectionner un dosage approprié d'un promédicament PBA sur la base de traitements antérieurs administrés au patient. Les procédés sont applicables à la sélection ou à la modification d'un schéma posologique pour un patient recevant un médicament d'épuration d'azote résiduaire administré par voie orale, et à la surveillance de patients recevant de tels médicaments.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)