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1. (WO2010025238) KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF A 3-ARYL-3-HYDROXYPROPANAMINE FROM A 3-ARYL-3-KETOPROPANAMINE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/025238    International Application No.:    PCT/US2009/055175
Publication Date: 04.03.2010 International Filing Date: 27.08.2009
IPC:
C12N 9/02 (2006.01), C12N 15/53 (2006.01), C12P 7/00 (2006.01)
Applicants: CODEXIS, INC. [US/US]; 200 Penobscot Drive Redwood City, California 94063 (US) (For All Designated States Except US).
SAVILE, Christopher [CA/US]; (US) (For US Only).
GRUBER, John, M. [US/US]; (US) (For US Only).
MUNDORFF, Emily [US/US]; (US) (For US Only).
HUISMAN, Gjalt, W. [US/US]; (US) (For US Only).
COLLIER, Steven, J. [GB/SG]; (SG) (For US Only)
Inventors: SAVILE, Christopher; (US).
GRUBER, John, M.; (US).
MUNDORFF, Emily; (US).
HUISMAN, Gjalt, W.; (US).
COLLIER, Steven, J.; (SG)
Agent: MACKNIGHT, Kamrin, T.; Codexis, Inc. 200 Penobscot Drive Redwood City, California 94063 (US)
Priority Data:
61/092,321 27.08.2008 US
Title (EN) KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF A 3-ARYL-3-HYDROXYPROPANAMINE FROM A 3-ARYL-3-KETOPROPANAMINE
(FR) POLYPEPTIDES DE KÉTORÉDUCTASE SERVANT À PRÉPARER UNE 3-ARYL-3-HYDROXYPROPANAMINE À PARTIR D'UNE 3-ARYL-3-KÉTOPROPANAMINE
Abstract: front page image
(EN)The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N,N-dimethyl-3-keto-3-(2-thienyl)-1-ketopropanamine to (S)-N,N-dimethyl-3-hydroxy-3-(2-thienyl)-1-propanamine.
(FR)L'invention concerne des enzymes kétoréductase obtenues par génie génétique et possédant des propriétés améliorées par rapport à une enzyme kétoréductase naturelle de type sauvage. Elle concerne également des polynucléotides codant ces enzymes kétoréductase, des cellules hôtes capables d'exprimer lesdites enzymes et des procédés d'utilisation desdites enzymes afin d'effectuer la synthèse d'une variété de composés chiraux. Les polypeptides de kétoréductase obtenue par génie génétique sont optimisés afin de catalyser la conversion de N,N-diméthyl-3-kéto-3-(2-thiényl)-1-kétopropanamine en (S)-N,N-diméthyl-3-hydroxy-3-(2-thiényl)-1-propanamine.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)