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1. (WO2010025177) METHOD AND COMPOSITIONS FOR ENHANCED ANTI-TUMOR EFFECTOR FUNCTIONING OF T CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/025177    International Application No.:    PCT/US2009/055029
Publication Date: 04.03.2010 International Filing Date: 26.08.2009
IPC:
C07K 14/435 (2006.01), C07H 21/00 (2006.01), A61K 48/00 (2006.01)
Applicants: CITY OF HOPE [US/US]; 1500 East Duarte Road Duarte, CA 91010-0269 (US) (For All Designated States Except US).
JENSEN, Michael [US/US]; (US) (For US Only)
Inventors: JENSEN, Michael; (US)
Agent: CASSIDY, Martha; (US)
Priority Data:
61/091,915 26.08.2008 US
Title (EN) METHOD AND COMPOSITIONS FOR ENHANCED ANTI-TUMOR EFFECTOR FUNCTIONING OF T CELLS
(FR) PROCÉDÉ ET COMPOSITIONS POUR FONCTIONNEMENT AMÉLIORÉ D’EFFECTEUR ANTITUMORAL DE LYMPHOCYTES T
Abstract: front page image
(EN)Integration of costimulatory signaling domains within a tumor targeting chimeric antigen receptor (CAR), such as the IL13Rα2 specific IL13-zetakine (IL13ζ), enhances T cell-mediated responses against tumors even in the absence of expressed ligands for costimulatory receptors.
(FR)La présente invention concerne l’intégration de domaines de signalisation costimulateurs dans un récepteur d’antigène chimère (CAR) ciblant une tumeur, tel que IL13-zétakine spécifique de IL13Rα2 (IL13ζ), qui augmente les réponses véhiculées par les lymphocytes T contre des tumeurs, même en l’absence de ligands exprimés pour des récepteurs costimulateurs.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)