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1. WO2010024405 - IFN TYPE-1 PRODUCTION INHIBITOR AND METHOD FOR SEARCHING FOR SAME

Publication Number WO/2010/024405
Publication Date 04.03.2010
International Application No. PCT/JP2009/065105
International Filing Date 28.08.2009
IPC
A61K 31/70 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
A61K 48/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61P 3/10 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
A61P 17/06 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
06Antipsoriatics
A61P 19/02 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
A61P 29/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
CPC
A61K 31/70
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
A61P 17/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
06Antipsoriatics
A61P 19/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
Applicants
  • 独立行政法人理化学研究所 RIKEN [JP]/[JP] (AllExceptUS)
  • 改正 恒康 KAISHO, Tsuneyasu [JP]/[JP] (UsOnly)
  • 星野 克明 HOSHINO, Katsuaki [JP]/[JP] (UsOnly)
  • 杉山 孝弘 SUGIYAMA, Takahiro [JP]/[JP] (UsOnly)
Inventors
  • 改正 恒康 KAISHO, Tsuneyasu
  • 星野 克明 HOSHINO, Katsuaki
  • 杉山 孝弘 SUGIYAMA, Takahiro
Agents
  • 高島 一 TAKASHIMA, Hajime
Priority Data
2008-22019328.08.2008JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) IFN TYPE-1 PRODUCTION INHIBITOR AND METHOD FOR SEARCHING FOR SAME
(FR) INHIBITEUR DE LA PRODUCTION DE L'IFN DE TYPE-1 ET SA MÉTHODE DE RECHERCHE
(JA) I型IFNの産生阻害剤、及びその探索方法
Abstract
(EN) It is found that Spi-B can act cooperatively with IRF-7 to induce the production of IFN type-I.  Based on this finding, it becomes possible to provide: an IFN type-I production inhibitor comprising an antisense nucleic acid or siRNA for Spi-B or an expression vector capable of expressing the antisense nucleic acid or the siRNA; a method for searching for a substance capable of inhibiting the production of IFN type-I, which comprises selecting a substance that inhibits the expression or function of Spi-B as the substance capable of inhibiting the production of IFN type-I; an IFN type-I production inducer comprising a combination of an expression vector capable of expressing Spi-B and an expression vector capable of expressing IRF-7; and others.
(JA)  Spi-BがIRF-7と協調してI型IFN産生を誘導することが明らかとなった。この知見に基づき、本発明は、Spi-Bに対するアンチセンス核酸又はsiRNA、或いはそれらを発現し得る発現ベクターを含む、I型IFN産生阻害剤;Spi-Bの発現又は機能を抑制する物質を、I型IFN産生を阻害し得る物質として選択することを含む、I型IFN産生を阻害し得る物質の探索方法;Spi-Bを発現し得る発現ベクターとIRF-7を発現し得る発現ベクターを組み合わせてなる、I型IFN産生誘導剤等を提供する。
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