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Pub. No.:    WO/2010/024384    International Application No.:    PCT/JP2009/065072
Publication Date: 04.03.2010 International Filing Date: 28.08.2009
Chapter 2 Demand Filed:    23.04.2010    
A61K 45/00 (2006.01), A61K 31/7088 (2006.01), A61K 31/7105 (2006.01), A61K 31/7115 (2006.01), A61K 48/00 (2006.01), A61P 1/16 (2006.01), A61P 31/14 (2006.01), A61P 43/00 (2006.01)
Applicants: OSAKA UNIVERSITY [JP/JP]; 1-1, Yamadaoka, Suita-shi, Osaka 5650871 (JP) (For All Designated States Except US).
MORIISHI, Kohji [JP/JP]; (JP) (For US Only).
MATSUURA, Yoshiharu [JP/JP]; (JP) (For US Only)
Inventors: MORIISHI, Kohji; (JP).
MATSUURA, Yoshiharu; (JP)
Agent: Saegusa & Partners; Kitahama TNK Building, 1-7-1, Doshomachi, Chuo-ku, Osaka-shi, Osaka 5410045 (JP)
Priority Data:
2008-221980 29.08.2008 JP
(JA) 抗C型肝炎ウイルス組成物
Abstract: front page image
(EN)Disclosed is an anti-hepatitis C virus composition containing a substance capable of inhibiting the expression or function of PA28γ gene. Also disclosed is a method for preventing the infection with a hepatitis C virus or inhibiting the proliferation of a hepatitis C virus, which comprises a step of administering the composition to a subject. Further disclosed is a method for screening for an active ingredient for an anti-hepatitis C virus composition, which comprises a step of selecting a substance capable of inhibiting the expression or function of PA28γ gene.
(FR)La présente invention concerne une composition d'antivirus de l'hépatite C contenant une substance capable d'inhiber l'expression de la fonction du gène PA28γ. L'invention porte en outre sur un procédé de prévention de l'infection par un virus de l'hépatite C ou d'inhibition de la prolifération d'un virus de l'hépatite C, qui comprend une étape consistant à administrer ladite composition à un sujet. L'invention a également trait à un procédé de criblage d'un principe actif pour une composition d'antivirus de l'hépatite C, qui comprend une étape de sélection d'une substance capable d'inhiber l'expression ou la fonction du gène PA28γ.
(JA) 本発明はPA28γ遺伝子の発現又は機能を抑制する物質を含む抗C型肝炎ウイルス組成物、前記組成物を被験体に投与する工程を含むC型肝炎ウイルス感染予防又は増殖抑制方法、並びに、PA28γ遺伝子の発現又は機能を阻害する物質を選択する工程を備えた抗C型肝炎ウイルス組成物の有効成分のスクリーニング方法を提供する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)