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1. WO2010024118 - NOVEL RECOMBINANT PROTEIN HAVING CASPASE RECRUITMENT DOMAIN APPLIED THERETO, AND USE THEREOF

Publication Number WO/2010/024118
Publication Date 04.03.2010
International Application No. PCT/JP2009/064218
International Filing Date 12.08.2009
Chapter 2 Demand Filed 21.06.2010
IPC
C12N 15/09 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
A61K 38/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 39/39 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
39characterised by the immunostimulating additives, e.g. chemical adjuvants
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 37/02 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
A61P 37/08 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
08Antiallergic agents
CPC
A61K 2039/55516
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55511Organic adjuvants
55516Proteins; Peptides
A61K 2039/55561
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55511Organic adjuvants
55561CpG containing adjuvants; Oligonucleotide containing adjuvants
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
A61K 39/145
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
145Orthomyxoviridae, e.g. influenza virus
A61K 39/39
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
39characterised by the immunostimulating additives, e.g. chemical adjuvants
Applicants
  • 公立大学法人横浜市立大学 Public University Corporation Yokohama City University [JP]/[JP] (AllExceptUS)
  • 武下 文彦 TAKESHITA, Fumihiko [JP]/[JP] (UsOnly)
  • 小檜山 康司 KOBIYAMA, Kouji [JP]/[JP] (UsOnly)
  • 奥田 研爾 OKUDA, Kenji [JP]/[JP] (UsOnly)
Inventors
  • 武下 文彦 TAKESHITA, Fumihiko
  • 小檜山 康司 KOBIYAMA, Kouji
  • 奥田 研爾 OKUDA, Kenji
Agents
  • 間山 世津子 MAYAMA, Setsuko
Priority Data
2008-22095629.08.2008JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) NOVEL RECOMBINANT PROTEIN HAVING CASPASE RECRUITMENT DOMAIN APPLIED THERETO, AND USE THEREOF
(FR) NOUVELLE PROTÉINE RECOMBINANTE À LAQUELLE EST APPLIQUÉ UN DOMAINE DE RECRUTEMENT DES CASPASES ET SON UTILISATION
(JA) カスパーゼリクルートメントドメインを応用した新規リコンビナントタンパク及びその用途
Abstract
(EN) Disclosed is a substance which can achieve immunomodulation through a mechanism that is different from those of conventional TLR ligands. Specifically disclosed are: a fusion molecule comprising a caspase recruitment domain and a nuclear localization signal; a pharmaceutical composition, an immunomodulating agent, a vaccine adjuvant, an anti-allergic agent and an anti-cancer agent each comprising the fusion molecule; and an immunomodulating agent, a vaccine adjuvant and an anti-allergic agent each comprising a substance capable of acting as an agonist or antagonist of an innate immune signaling through nuclear DNA helicase II.
(FR) L’invention concerne une substance qui peut réaliser une immunomodulation par un mécanisme qui est différent de celui des ligands TLR classiques. L’invention concerne spécifiquement : une molécule de fusion qui comprend un domaine de recrutement des caspases et un signal de localisation nucléaire; une composition pharmaceutique, un agent d’immunomodulation, un adjuvant de vaccin, un agent anti-allergique et un agent anti-cancer, comprenant chacun la molécule de fusion; et un agent d’immunomodulation, un adjuvant de vaccin et un agent anti-allergique comprenant chacun une substance capable d’agir en tant qu’agoniste ou antagoniste d’une signalisation immunitaire naturelle par l’ADN hélicase II nucléaire.
(JA)  従来型のTLRリガンドとは異なる機序で免疫調節することができる物質を提供する。 カスパーゼリクルートメントドメインと核移行シグナルとを含む融合分子。前記融合分子を含む、医薬組成物、免疫調節薬、ワクチンアジュバント、抗アレルギー薬及び抗癌剤。核DNAヘリカーゼIIを介する自然免疫シグナル伝達のアゴニスト又はアンタゴニストとして作用する物質を含む、免疫調節薬、ワクチンアジュバント及び抗アレルギー薬。
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