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1. (WO2010024118) NOVEL RECOMBINANT PROTEIN HAVING CASPASE RECRUITMENT DOMAIN APPLIED THERETO, AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/024118    International Application No.:    PCT/JP2009/064218
Publication Date: 04.03.2010 International Filing Date: 12.08.2009
Chapter 2 Demand Filed:    21.06.2010    
IPC:
C12N 15/09 (2006.01), A61K 38/00 (2006.01), A61K 39/39 (2006.01), A61P 35/00 (2006.01), A61P 37/02 (2006.01), A61P 37/08 (2006.01), C07K 19/00 (2006.01), C12N 1/15 (2006.01), C12N 1/19 (2006.01), C12N 1/21 (2006.01), C12N 5/10 (2006.01), C12N 9/50 (2006.01), C12P 21/02 (2006.01), C12Q 1/02 (2006.01), G01N 33/15 (2006.01), G01N 33/50 (2006.01)
Applicants: Public University Corporation Yokohama City University [JP/JP]; 22-2, Seto, Kanazawa-ku, Yokohama-shi, Kanagawa 2360027 (JP) (For All Designated States Except US).
TAKESHITA, Fumihiko [JP/JP]; (JP) (For US Only).
KOBIYAMA, Kouji [JP/JP]; (JP) (For US Only).
OKUDA, Kenji [JP/JP]; (JP) (For US Only)
Inventors: TAKESHITA, Fumihiko; (JP).
KOBIYAMA, Kouji; (JP).
OKUDA, Kenji; (JP)
Agent: MAYAMA, Setsuko; Nohki-kaikan Fourth Floor, 30-1, Tsuruyacho 3-chome, Kanagawa-ku, Yokohama-shi, Kanagawa 2210835 (JP)
Priority Data:
2008-220956 29.08.2008 JP
Title (EN) NOVEL RECOMBINANT PROTEIN HAVING CASPASE RECRUITMENT DOMAIN APPLIED THERETO, AND USE THEREOF
(FR) NOUVELLE PROTÉINE RECOMBINANTE À LAQUELLE EST APPLIQUÉ UN DOMAINE DE RECRUTEMENT DES CASPASES ET SON UTILISATION
(JA) カスパーゼリクルートメントドメインを応用した新規リコンビナントタンパク及びその用途
Abstract: front page image
(EN)Disclosed is a substance which can achieve immunomodulation through a mechanism that is different from those of conventional TLR ligands. Specifically disclosed are: a fusion molecule comprising a caspase recruitment domain and a nuclear localization signal; a pharmaceutical composition, an immunomodulating agent, a vaccine adjuvant, an anti-allergic agent and an anti-cancer agent each comprising the fusion molecule; and an immunomodulating agent, a vaccine adjuvant and an anti-allergic agent each comprising a substance capable of acting as an agonist or antagonist of an innate immune signaling through nuclear DNA helicase II.
(FR)L’invention concerne une substance qui peut réaliser une immunomodulation par un mécanisme qui est différent de celui des ligands TLR classiques. L’invention concerne spécifiquement : une molécule de fusion qui comprend un domaine de recrutement des caspases et un signal de localisation nucléaire; une composition pharmaceutique, un agent d’immunomodulation, un adjuvant de vaccin, un agent anti-allergique et un agent anti-cancer, comprenant chacun la molécule de fusion; et un agent d’immunomodulation, un adjuvant de vaccin et un agent anti-allergique comprenant chacun une substance capable d’agir en tant qu’agoniste ou antagoniste d’une signalisation immunitaire naturelle par l’ADN hélicase II nucléaire.
(JA) 従来型のTLRリガンドとは異なる機序で免疫調節することができる物質を提供する。 カスパーゼリクルートメントドメインと核移行シグナルとを含む融合分子。前記融合分子を含む、医薬組成物、免疫調節薬、ワクチンアジュバント、抗アレルギー薬及び抗癌剤。核DNAヘリカーゼIIを介する自然免疫シグナル伝達のアゴニスト又はアンタゴニストとして作用する物質を含む、免疫調節薬、ワクチンアジュバント及び抗アレルギー薬。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)