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1. (WO2010023605) METHOD FOR THE IDENTIFICATION OF GENES INVOLVED IN NEURODEGENERATIVE PROCESSES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/023605    International Application No.:    PCT/IB2009/053681
Publication Date: 04.03.2010 International Filing Date: 20.08.2009
IPC:
C12N 15/12 (2006.01), C12N 15/00 (2006.01), C12Q 1/68 (2006.01)
Applicants: INIS BIOTECH LLC [US/US]; 203 NE Front Street, Suite 101 Milford, Kent County, Delaware 19963 (US) (For All Designated States Except US).
FUNDACION INSTITUTO LELOIR [AR/AR]; Av. Patricias Argentinas 435 Ciudad Autónoma de Buenos Aires, C1405BWE (AR) (For All Designated States Except US).
CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET) [AR/AR]; Rivadavia 1906 3ºF Ciudad Autónoma de Buenos Aires, C1033AAW (AR) (For All Designated States Except US).
CERIANI, Maria, Fernanda [AR/AR]; (AR) (For US Only).
REZAVAL, Carolina [AR/AR]; (AR) (For US Only).
BERNI, Jimena [AR/AR]; (AR) (For US Only)
Inventors: CERIANI, Maria, Fernanda; (AR).
REZAVAL, Carolina; (AR).
BERNI, Jimena; (AR)
Priority Data:
P080103729 27.08.2008 AR
Title (EN) METHOD FOR THE IDENTIFICATION OF GENES INVOLVED IN NEURODEGENERATIVE PROCESSES
(FR) PROCÉDÉ D’IDENTIFICATION DE GÈNES IMPLIQUÉS DANS DES PROCÉDÉS NEURODÉGÉNÉRATIFS
Abstract: front page image
(EN)A method for the identification of genes involved in neurodegenerative processes, detectable by the late onset of a phenotype associated with neurodegeneration, by means of a genetic screen of deregulated genes, which comprises the measurement of sleep-wake cycle activity schemes in different stages of life, young and adult, of individuals of an animal model, such as Drosophila. A mutant fly whose genome comprises a disruption in its enabled gene, with decrease of the enabled gene expression, and exhibiting a late onset neurodegenerative phenotype in adulthood.
(FR)L’invention concerne un procédé d’identification de gènes impliqués dans des procédés neurodégénératifs, détectables par l’apparition tardive d’un phénotype associé avec la neurodégénération, au moyen d’un criblage génétique des gènes dérégulés, qui comprend la mesure de schémas d’activité du cycle veille-sommeil à différents stades de la vie, jeunes et adultes, d’individus d’un modèle animal, tel que Drosophila. L’invention concerne également une mouche mutante dont le génome comprend une perturbation de son gène activé, avec une diminution de l’expression du gène activé, et qui présente une apparition tardive d’un phénotype neurodégénératif au stade adulte.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)