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1. (WO2010023383) NOVEL METHOD FOR RESOLVING THE ENANTIOMERS OF (3,4-DIMETHOXY­BICYCLO[4.2.0]OCTA-13,5-TRIEN-7-YL)NITRILE AND USE IN THE SYNTHESIS OF IVABRADINE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/023383    International Application No.:    PCT/FR2009/001036
Publication Date: 04.03.2010 International Filing Date: 27.08.2009
IPC:
C07D 223/16 (2006.01)
Applicants: LES LABORATOIRES SERVIER [FR/FR]; 35, rue de Verdun F-92284 Suresnes Cedex (FR) (For All Designated States Except US).
LERESTIF, Jean-Michel [FR/FR]; (FR) (For US Only).
LECOUVE, Jean-Pierre [FR/FR]; (FR) (For US Only).
DRON, Daniel [FR/FR]; (FR) (For US Only).
GOJON, Eric [FR/FR]; (FR) (For US Only).
PHAN, Maryse [FR/FR]; (FR) (For US Only)
Inventors: LERESTIF, Jean-Michel; (FR).
LECOUVE, Jean-Pierre; (FR).
DRON, Daniel; (FR).
GOJON, Eric; (FR).
PHAN, Maryse; (FR)
Common
Representative:
LES LABORATOIRES SERVIER [FR/FR]; 35, rue de Verdun F-92284 Suresnes cedex (FR)
Priority Data:
0804755 29.08.2008 FR
Title (EN) NOVEL METHOD FOR RESOLVING THE ENANTIOMERS OF (3,4-DIMETHOXY­BICYCLO[4.2.0]OCTA-13,5-TRIEN-7-YL)NITRILE AND USE IN THE SYNTHESIS OF IVABRADINE
(FR) NOUVEAU PROCEDE DE RESOLUTION DES ENANTIOMERES DU (3,4- DIMETHOXY-BICYCLO[4.2.0]OCTA-13,5-TRIEN-7-YL)NITRILE ET APPLICATION A LA SYNTHESE DE L'IVABRADINE
Abstract: front page image
(EN)Method for optical resolution of the compound of formula (I): by chiral chromatography. Use in the synthesis of ivabradine, of addition salts thereof with a pharmaceutically acceptable acid and of hydrates thereof.
(FR)Procédé de résolution optique du composé de formule (I) par chromatographie chirale. Application à la synthèse de l'ivabradine, de ses sels d'addition à un acide pharmaceutiquement acceptable et de leurs hydrates.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: French (FR)
Filing Language: French (FR)