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1. (WO2010022979) CLOSTRIDIAL NEUROTOXINS WITH ALTERED PERSISTENCY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/022979    International Application No.:    PCT/EP2009/006272
Publication Date: 04.03.2010 International Filing Date: 28.08.2009
IPC:
C07K 14/33 (2006.01)
Applicants: MERZ PHARMA GMBH & CO. KGAA [DE/DE]; 100 Eckenheimer Landstrasse 60318 Frankfurt (Main) (DE) (For All Designated States Except US).
FREVERT, Juergen [DE/DE]; (DE) (For US Only)
Inventors: FREVERT, Juergen; (DE)
Agent: RICKER, Mathias; Wallinger Ricker Schlotter Foerstl Zweibrückenstraße 5-7 80331 München (DE)
Priority Data:
08015287.9 29.08.2008 EP
61/190,558 29.08.2008 US
Title (EN) CLOSTRIDIAL NEUROTOXINS WITH ALTERED PERSISTENCY
(FR) NEUROTOXINES CLOSTRIDIALES AVEC PERSISTANCE ALTÉRÉE
Abstract: front page image
(EN)The invention relates to a polypeptide comprising: (a) a HC-domain or fragment thereof of the neurotoxic component of a clostridial toxin; and (b) a first LC domain or fragment thereof of the neurotoxic component of a clostridial toxin; and (c) at least one further LC domain or fragment thereof of the neurotoxic component of a clostridial toxin wherein the first and the at least one further LC domain may be the same or different from each other, and wherein each of said fragments of said first and of said at least one further LC domain still exhibits proteolytic activity.
(FR)L’invention concerne un polypeptide qui comprend : (a) un domaine HC ou un fragment de celui-ci du composant neurotoxique d’une toxine clostridiale ; et (b) un premier domaine LC ou un fragment de celui-ci du composant neurotoxique d’une toxine clostridiale ; et (c) au moins un autre domaine LC ou un fragment de celui-ci du composant neurotoxique d’une toxine clostridiale, dont le premier et ledit autre domaine LC peuvent être identiques ou différents l’un de l’autre, et dont chacun desdits fragments dudit premier et dudit autre domaine LC présente encore une activité protéolytique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)