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1. WO2010011890 - CANCER PEPTIDE THERAPEUTICS

Publication Number WO/2010/011890
Publication Date 28.01.2010
International Application No. PCT/US2009/051643
International Filing Date 24.07.2009
IPC
A61K 38/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08Peptides having 5 to 11 amino acids
C12N 15/62 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
62DNA sequences coding for fusion proteins
CPC
A61K 38/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08Peptides having 5 to 11 amino acids
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07K 14/4738
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
4701not used
4738Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR
Applicants
  • INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION [US]/[US] (AllExceptUS)
  • HICKEY, Robert, J. [US]/[US] (UsOnly)
  • MALKAS, Linda, H. [US]/[US] (UsOnly)
Inventors
  • HICKEY, Robert, J.
  • MALKAS, Linda, H.
Agents
  • ADDISON, Bradford G.
Priority Data
61/083,39324.07.2008US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CANCER PEPTIDE THERAPEUTICS
(FR) THÉRAPIE PEPTIDIQUE CONTRE LE CANCER
Abstract
(EN)
Peptide variants corresponding to cancer specific isoform of proliferating cell nuclear antigen (caPCNA) interfere with intracellular protein-protein interaction, thereby causing a reduction in the proliferative potential of cancer. Cell-permeable caPCNA-derived peptides and their variants serve as therapeutic compositions to reduce the proliferation of cancer cells and also augment cytotoxic effects of existing cancer therapy. These compositions are also useful for chemoprevention of cancer.
(FR)
La présente invention concerne des variantes peptidiques correspondant à une isoforme spécifique au cancer d'antigène nucléaire de prolifération cellulaire (caPCNA), qui interfèrent avec l'interaction protéine-protéine intracellulaire, entraînant ainsi une réduction du potentiel prolifératif du cancer. Des peptides dérivés de caPCNA perméables aux cellules et leurs variantes servent de compositions thérapeutiques pour réduire la prolifération de cellules cancéreuses, et pour augmenter les effets cytotoxiques de la thérapie cancéreuse existante. Ces compositions sont également utiles pour la chimioprévention du cancer.
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