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1. (WO2010010190) NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES
Latest bibliographic data on file with the International Bureau   
Pub. No.: WO/2010/010190 International Application No.: PCT/EP2009/059604
Publication Date: 28.01.2010 International Filing Date: 24.07.2009
IPC:
C07D 471/04 (2006.01) ,A61K 31/437 (2006.01) ,A61P 19/02 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
437
the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
02
for joint disorders, e.g. arthritis, arthrosis
Applicants:
MENET, Christel Jeanne Marie [FR/FR]; BE (UsOnly)
VAN ROMPAEY, Luc Juliaan Corina [BE/BE]; BE (UsOnly)
FLETCHER, Stephen Robert [GB/FR]; FR (UsOnly)
BLANC, Javier [ES/BE]; BE (UsOnly)
JOUANNIGOT, Nolwenn [FR/FR]; FR (UsOnly)
HODGES, Alastair James [GB/GB]; GB (UsOnly)
SMITS, Koen Kurt [BE/BE]; BE (UsOnly)
GALAPAGOS NV [BE/BE]; Industriepark Mechelen Noord Generaal De Wittelaan L11/A3 B-2800 Mechelen, BE (AllExceptUS)
Inventors:
MENET, Christel Jeanne Marie; BE
VAN ROMPAEY, Luc Juliaan Corina; BE
FLETCHER, Stephen Robert; FR
BLANC, Javier; BE
JOUANNIGOT, Nolwenn; FR
HODGES, Alastair James; GB
SMITS, Koen Kurt; BE
Agent:
NICHOL, Maria; GB
Priority Data:
61/135,92025.07.2008US
61/220,68526.06.2009US
Title (EN) NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES
(FR) NOUVEAUX COMPOSÉS UTILES POUR LE TRAITEMENT DE MALADIES DÉGÉNÉRATIVES ET INFLAMMATOIRES
Abstract:
(EN) [1,2,4]Triazolo[1,5-a]pyridine compounds are disclosed that have a formula represented by the formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non- limiting example, diseases involving cartilage degradation, bone and/or joint degradation, for example osteoarthritis; and/or conditions involving inflammation or immune responses, such as Crohn's disease, rheumatoid arthritis, psoriasis, allergic airways disease (e.g. asthma, rhinitis), juvenile idiopathic arthritis, colitis, inflammatory bowel diseases, endotoxin-driven disease states (e.g. complications after bypass surgery or chronic endotoxin states contributing to e.g. chronic cardiac failure), diseases involving impairment of cartilage turnover (e.g diseases involving the anabolic stimulation of chondrocytes), congenital cartilage malformations, diseases associated with hypersecretion of IL6, transplantation rejection (e.g. organ transplant rejection) and proliferative diseases.
(FR) La présente invention concerne des composés [1,2,4]-triazolo-[1,5-a]-pyridine qui ont la formule représentée par la formule (I). Les composés peuvent être préparés sous forme de compositions pharmaceutiques, et peuvent être utilisés pour la prévention et le traitement d'une variété d'états chez des mammifères y compris des humains, comprenant, en tant qu'exemple non limitant, des maladies comprenant la dégradation du cartilage, la dégradation osseuse et/ou articulaire, par exemple l'ostéoarthrite ; et/ou des états comprenant des réponses inflammatoires ou immunitaires, telles que la maladie de Crohn, l’arthrite rhumatoïde, le psoriasis, une maladie allergique des voies respiratoires (par exemple l'asthme, la rhinite), l’arthrite idiopathique juvénile, la rectocolite, les maladies inflammatoires de l'intestin, des états pathologiques induits par l'endotoxine (par exemple des complications après une chirurgie de pontage ou des états chroniques liés à l'endotoxine contribuant par exemple à une insuffisance cardiaque chronique), des maladies comprenant une incapacité de renouvellement du cartilage (par exemple des maladies comprenant la stimulation anabolique de chondrocytes), des malformations congénitales du cartilage, des maladies associées à une hypersécrétion de l'IL6, un rejet de la transplantation (par exemple un rejet d'un organe transplanté) et des maladies prolifératives.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)