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1. WO2010010184 - [1, 2, 4] TRIAZOLO [1, 5-A] PYRIDINES AS JAK INHIBITORS

Publication Number WO/2010/010184
Publication Date 28.01.2010
International Application No. PCT/EP2009/059595
International Filing Date 24.07.2009
IPC
C07D 471/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/437 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61P 19/02 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
A61P 29/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
CPC
A61P 19/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • GALAPAGOS NV [BE]/[BE] (AllExceptUS)
  • MENET, Christel, Jeanne, Marie [FR]/[BE] (UsOnly)
  • BLANC, Javier [ES]/[BE] (UsOnly)
  • HODGES, Alastair, James [GB]/[GB] (UsOnly)
  • BURLI, Roland, Werner [CH]/[GB] (UsOnly)
  • BRECCIA, Perla [IT]/[GB] (UsOnly)
  • BLACKABY, Wesley, Peter [GB]/[GB] (UsOnly)
  • VAN ROMPAEY, Luc, Juliaan, Corina [BE]/[BE] (UsOnly)
  • FLETCHER, Stephen, Robert [GB]/[FR] (UsOnly)
Inventors
  • MENET, Christel, Jeanne, Marie
  • BLANC, Javier
  • HODGES, Alastair, James
  • BURLI, Roland, Werner
  • BRECCIA, Perla
  • BLACKABY, Wesley, Peter
  • VAN ROMPAEY, Luc, Juliaan, Corina
  • FLETCHER, Stephen, Robert
Agents
  • NICHOL, Maria
Priority Data
61/137,06025.07.2008US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) [1, 2, 4] TRIAZOLO [1, 5-A] PYRIDINES AS JAK INHIBITORS
(FR) [1, 2, 4]TRIAZOLO[1, 5-A]PYRIDINES UTILISÉES COMME INHIBITEURS DE JAK
Abstract
(EN) Novel [1,2,4]triazolo[1,5-a]pyridine compounds are disclosed that have a Formula represented by the following: (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, joint disease, inflammation, and others.
(FR) Cette invention concerne de nouveaux composés [1,2,4]triazolo[1,5-a]pyridine représentés par la formule ci-après. Les composés peuvent être préparés en tant que compositions pharmaceutiques et peuvent être utilisés dans la prévention et le traitement de différentes affections chez le mammifère, y compris l’homme, notamment les maladies articulaires et l’inflammation.
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