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1. WO2010009334 - METHOD FOR PREPARING LARGAZOLE ANALOGS AND USES THEREOF

Publication Number WO/2010/009334
Publication Date 21.01.2010
International Application No. PCT/US2009/050878
International Filing Date 16.07.2009
IPC
A01N 43/78 2006.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
72having rings with nitrogen atoms and oxygen or sulfur atoms, as ring hetero atoms
74five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
781,3-Thiazoles; Hydrogenated 1,3-thiazoles
A61K 31/42 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
42Oxazoles
A61K 31/425 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425Thiazoles
CPC
A61K 31/429
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
425Thiazoles
429condensed with heterocyclic ring systems
A61K 39/39558
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
39533against materials from animals
39558against tumor tissues, cells, antigens
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 7/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
C07D 498/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
498Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
12in which the condensed system contains three hetero rings
18Bridged systems
Applicants
  • COLORADO STATE UNIVERSITY RESEARCH FOUNDATION [US]/[US] (AllExceptUS)
  • DANA-FARBER CANCER INSTITUTE, INC. [US]/[US] (AllExceptUS)
  • WILLIAMS, Robert, M. [US]/[US] (UsOnly)
  • BRADNER, James, E. [US]/[US] (UsOnly)
  • BOWERS, Albert [US]/[US] (UsOnly)
  • NEWKIRK, Tenaya [US]/[US] (UsOnly)
  • YOUNGMAN, Ann, E. [US]/[US] (UsOnly)
Inventors
  • WILLIAMS, Robert, M.
  • BRADNER, James, E.
  • BOWERS, Albert
  • NEWKIRK, Tenaya
  • YOUNGMAN, Ann, E.
Agents
  • BRATSCHUN, Thomas, D.
Priority Data
61/081,65317.07.2008US
61/151,08709.02.2009US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR PREPARING LARGAZOLE ANALOGS AND USES THEREOF
(FR) PROCÉDÉ DE PRÉPARATION D’ANALOGUES DE LARGAZOLE ET SES UTILISATIONS
Abstract
(EN)
Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
(FR)
L’invention concerne des analogues de largazole. L’invention concerne en outre des méthodes de traitement du cancer et de troubles sanguins qui utilisent le largazole, des analogues du largazole ainsi que des compositions pharmaceutiques qui les comprennent. L’invention concerne en outre des procédés de préparation d’analogues du largazole.
Latest bibliographic data on file with the International Bureau