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1. WO2010009332 - BINDING AND INHIBITING 5-HT4 RECEPTOR

Publication Number WO/2010/009332
Publication Date 21.01.2010
International Application No. PCT/US2009/050875
International Filing Date 16.07.2009
IPC
A61K 31/54 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
54having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame
CPC
A61K 31/54
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
54having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Applicants
  • IMMUNE CONTROL, INC. [US]/[US] (AllExceptUS)
  • ROTH, Stephen [US]/[US] (UsOnly)
  • ZOPF, David [US]/[US] (UsOnly)
Inventors
  • ROTH, Stephen
  • ZOPF, David
Agents
  • NGUYEN, Quang, D.
Priority Data
61/135,27318.07.2008US
61/143,55309.01.2009US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) BINDING AND INHIBITING 5-HT4 RECEPTOR
(FR) RÉCEPTEUR 5-HT4 DE LIAISON ET D'INHIBITION
Abstract
(EN)
The present invention relates to compositions that bind to 5-HT4 receptors and inhibit proliferation of activated lymphocytes. The invention also provides methods for inhibiting proliferation and inducing cell death in activated immune cells, as well methods for treating diseases associated with activated immune cells by administering 5-HT4 receptor ligands.
(FR)
L'invention concerne des compositions qui se lient à des récepteurs 5-HT4 et inhibent une prolifération de lymphocytes activés. L'invention fournit également des procédés pour inhiber une prolifération et induire une mort cellulaire dans des cellules immunes activées, de même que des procédés pour traiter des maladies associées à des cellules immunes activées par administration de ligands du récepteur 5-HT4.
Also published as
Latest bibliographic data on file with the International Bureau