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1. WO2010006219 - USE OF SCAFFOLD COMPRISING FIBRIN FOR DELIVERY OF STEM CELLS

Publication Number WO/2010/006219
Publication Date 14.01.2010
International Application No. PCT/US2009/050178
International Filing Date 09.07.2009
IPC
A61L 27/22 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
14Macromolecular materials
22Polypeptides or derivatives thereof
A61L 27/38 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
36containing ingredients of undetermined constitution or reaction products thereof
38Animal cells
CPC
A61L 27/225
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
14Macromolecular materials
22Polypeptides or derivatives thereof ; , e.g. degradation products
225Fibrin; Fibrinogen
A61L 27/3834
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
36containing ingredients of undetermined constitution or reaction products thereof ; , e.g. transplant tissue, natural bone, extracellular matrix
38containing added animal cells
3804characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
3834Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
A61P 9/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applicants
  • BAXTER INTERNATIONAL INC. [US]/[US] (AllExceptUS)
  • BAXTER HEALTHCARE S.A. (AllExceptUS)
  • MOTLAGH, Delara [US]/[US] (UsOnly)
  • AMRANI, David, L. [US]/[US] (UsOnly)
  • DIORIO, James, P. [US]/[US] (UsOnly)
Inventors
  • MOTLAGH, Delara
  • AMRANI, David, L.
  • DIORIO, James, P.
Agents
  • JANULIS, Lynn, L.
Priority Data
61/134,67209.07.2008US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) USE OF SCAFFOLD COMPRISING FIBRIN FOR DELIVERY OF STEM CELLS
(FR) UTILISATION D'UN SUPPORT COMPORTANT DE LA FIBRINE POUR DISTRIBUTION DE CELLULES SOUCHES
Abstract
(EN)
The invention generally relates to the field of delivery of cells to desired tissue sites, prolonged retention of the cells at the sites, and integration of cells into an area of interest for increased therapeutic effect. The invention provides, in part, compositions and methods for treating ischemia in a subject in need thereof. In some aspects, the methods of treatment comprise the administration of a fibrin scaffold or fibrin clot comprising stem cells.
(FR)
L'invention concerne de manière générale le domaine de la distribution de cellules à des sites de tissu souhaités, la retenue prolongée des cellules au niveau des sites et l'intégration des cellules dans une zone d’intérêt pour un effet thérapeutique accru. L'invention concerne en particulier des compositions et des procédés pour traiter une ischémie chez un sujet qui en souffre. Selon certains aspects, les procédés de traitement comportent l'administration d'un support de fibrine ou d'un caillot de fibrine comportant des cellules souches.
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