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1. (WO2010006200) TRIGGERED RELEASE OF DRUGS FROM POLYMER PARTICLES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/006200 International Application No.: PCT/US2009/050158
Publication Date: 14.01.2010 International Filing Date: 09.07.2009
IPC:
A61K 47/48 (2006.01) ,A61K 38/48 (2006.01) ,A61K 9/16 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43
Enzymes; Proenzymes; Derivatives thereof
46
Hydrolases (3)
48
acting on peptide bonds (3.4)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
16
Agglomerates; Granulates; Microbeadlets
Applicants:
ROY, Krishnendu [IN/US]; US (UsOnly)
WANAKULE, Prinda [US/US]; US (UsOnly)
SINGH, Ankur [IN/US]; US (UsOnly)
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM [US/US]; 201 West 7th Street Austin, TX 78701, US (AllExceptUS)
Inventors:
ROY, Krishnendu; US
WANAKULE, Prinda; US
SINGH, Ankur; US
Agent:
FLORES, Edwin; US
Priority Data:
61/079,30509.07.2008US
Title (EN) TRIGGERED RELEASE OF DRUGS FROM POLYMER PARTICLES
(FR) LIBÉRATION DÉCLENCHÉE DE MÉDICAMENTS À PARTIR DE PARTICULES POLYMÈRES
Abstract:
(EN) The present invention includes compositions and methods for the controlled delivery of active agents, e.g., drugs, based on one or more release triggers found in the environment in which the active agent-loaded particle is located. The composition and methods include a polymer network having a polymer cross-linked by peptides that include one or more proteolytic cleavage sites.
(FR) La présente invention porte sur des compositions et des procédés pour l'administration contrôlée d'agents actifs, par exemple de médicaments, à base d'un ou plusieurs déclencheurs de libération trouvés dans l'environnement dans lequel les particules chargées d'agent actif sont situées. La composition et les procédés comprennent un réseau polymère ayant un polymère réticulé par des peptides qui comprennent un ou plusieurs sites de clivage protéolytiques.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)