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1. WO2010005465 - L-CARNITINE AND ALKANOYL L-CARNITINE PHYTATES AND PROCESS FOR PREPARING THE SAME

Publication Number WO/2010/005465
Publication Date 14.01.2010
International Application No. PCT/US2009/003522
International Filing Date 10.06.2009
IPC
A61K 31/14 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines, e.g. amantadine
14Quaternary ammonium compounds, e.g. edrophonium, choline
C07F 9/117 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
06without P-C bonds
08Esters of oxyacids of phosphorus
09Esters of phosphoric acids
117with cycloaliphatic alcohols
A61K 31/6615 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
66Phosphorus compounds
661Phosphorus acids or esters thereof not having P-C bonds, e.g. fosfosal, dichlorvos, malathion
6615Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid
C07C 229/22 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
229Compounds containing amino and carboxyl groups bound to the same carbon skeleton
02having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
04the carbon skeleton being acyclic and saturated
22the carbon skeleton being further substituted by oxygen atoms
CPC
C07C 229/22
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
229Compounds containing amino and carboxyl groups bound to the same carbon skeleton
02having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
04the carbon skeleton being acyclic and saturated
22the carbon skeleton being further substituted by oxygen atoms
C07F 9/117
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
06without P—C bonds
08Esters of oxyacids of phosphorus
09Esters of phosphoric acids
117with cycloaliphatic alcohols
Applicants
  • SCIAN LABORATORIES, LLC [US]/[US] (AllExceptUS)
  • CHEN, Jian [CN]/[US] (UsOnly)
Inventors
  • CHEN, Jian
Agents
  • HERMANN, Kirk, William
Priority Data
61/061,95616.06.2008US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) L-CARNITINE AND ALKANOYL L-CARNITINE PHYTATES AND PROCESS FOR PREPARING THE SAME
(FR) PHYTATES DE L-CARNITINE ET D’ALCANOYLE L-CARNITINE, ET LEUR PROCÉDÉ DE PRÉPARATION
Abstract
(EN)
Salts of L-carnitine and alkanoyl L-carnitines with phytic acid of general formula (I), and the process of preparing the same, wherein the mole ratio between the L-carnitine or its alkanoyl derivatives cation and phytic acid anion be within the range of 1 :1 to 6:1, wherein: n = 1-6; R1 is the phytate anion; R is either hydrogen, a straight alkanoyl group having 2-12 carbon atoms or a branched-chain alkanoyl group having 2-12 carbon atoms.
(FR)
Cette invention concerne des sels de L-carnitine et des alcanoyle L-carnitines avec acide phytique de formule générale (I), et leur procédé de préparation, le rapport molaire entre la L-carnitine ou son cation dérivés alcanoyle et anion acide phytique étant compris dans la gamme de 1:1 à 6:1, n valant de 1 à 6; R1 étant l’anion phytate; R étant de l’hydrogène, un groupe alcanoyle linéaire ayant de 2 à 12 atomes de carbone ou un groupe alcanoyle à chaîne ramifiée ayant de 2 à 12 atomes de carbone.
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