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1. WO2010005273 - TRANSGENIC ZEBRAFISH AND METHOD FOR MASS PRODUCTION OF HUMAN LACTOFERRIN USING THE SAME

Publication Number WO/2010/005273
Publication Date 14.01.2010
International Application No. PCT/KR2009/003832
International Filing Date 13.07.2009
IPC
C12N 15/11 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
CPC
A01K 2217/052
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2217Genetically modified animals
05Animals comprising random inserted nucleic acids (transgenic)
052inducing gain of function
A01K 2227/40
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2227Animals characterised by species
40Fish
A01K 2267/01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2267Animals characterised by purpose
01Animal expressing industrially exogenous proteins
A01K 67/0278
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67Rearing or breeding animals, not otherwise provided for; New breeds of animals
027New breeds of vertebrates
0275Genetically modified vertebrates, e.g. transgenic
0278Humanized animals, e.g. knockin
C07K 14/79
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
79Transferrins, e.g. lactoferrins, ovotransferrins
Applicants
  • 서울대학교산학협력단 SNU R&DB FOUNDATION [KR]/[KR] (AllExceptUS)
  • 주식회사 바이오노트 BIONOTE, INC. [KR]/[KR] (AllExceptUS)
  • 박재학 PARK, Jae Hak [KR]/[KR] (UsOnly)
  • 석승혁 SEOK, Seung Hyeok [KR]/[KR] (UsOnly)
  • 조영식 CHO, Young Shik [KR]/[KR] (UsOnly)
  • 하건우 HA, Gun Woo [KR]/[KR] (UsOnly)
  • 오진식 OH, Jin Sik [KR]/[KR] (UsOnly)
  • 오연경 OH, Youn Kyoung [KR]/[KR] (UsOnly)
Inventors
  • 박재학 PARK, Jae Hak
  • 석승혁 SEOK, Seung Hyeok
  • 조영식 CHO, Young Shik
  • 하건우 HA, Gun Woo
  • 오진식 OH, Jin Sik
  • 오연경 OH, Youn Kyoung
Agents
  • 손민 SON, Min
Priority Data
10-2008-006778611.07.2008KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) TRANSGENIC ZEBRAFISH AND METHOD FOR MASS PRODUCTION OF HUMAN LACTOFERRIN USING THE SAME
(FR) POISSON ZÈBRE TRANSGÉNIQUE ET SON UTILISATION POUR LA PRODUCTION EN GRANDE QUANTITÉ DE LACTOFERRINE HUMAINE
(KO) 인간 락토페린을 대량생산하기 위한 형질전환 제브라피쉬 및 이를 이용한 인간 락토페린의 대량생산방법
Abstract
(EN)
The present invention relates to zebrafish that mass produce human lactoferrin after being transformed with a recombinant expression vector containing the human lactoferrin gene, to a method for the mass production of human lactoferrin from said transgenic zebrafish, and to functional foods and animal feed additives containing said transgenic zebrafish as the active ingredient. According to the present invention, a large quantity of human lactoferrin can be obtained from transgenic zebrafish. Furthermore, the transgenic zebrafish can be used as an ingredient for functional foods and as an additive for animal feed.
(FR)
Production en grande quantité de lactoferrine humaine à partir de poisson zèbre modifié par un vecteur d'expression recombinant contenant le gène de la lactoferrine humaine, méthode de production en grande quantité de lactoferrine humaine à partir dudit poisson zèbre transgénique et alicaments et compléments pour alimentation animale renfermant ledit poisson zèbre comme ingrédient actif. Cette invention rend possible l'obtention de grandes quantités de lactoferrine à partir dudit poisson zèbre. De plus, le poisson zèbre lui-même peut entrer dans la composition d'alicaments et de compléments pour alimentation animale.
(KO)
본 발명은 인간 락토페린 유전자를 포함하는 재조합 발현 벡터로 형질전환되어 인간 락토페린을 대량생산하는 제브라피쉬, 상기 형질전환된 제브라피쉬로부터 인간 락토페린을 대량생산하는 방법, 및 상기 형질전환된 제브라피쉬를 유효성분으로 함유하는 건강기능식품 및 동물 사료 첨가제에 관한 것이다. 본 발명에 따르면 형질전환된 제브라피쉬로부터 인간 락토페린을 대량으로 쉽게 확보할 수 있고, 나아가 형질전환된 제브라피쉬 자체는 건강기능식품의 원료 및 동물 사료 첨가제로서 유용하게 사용할 수 있다.
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