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1. (WO2010003041) MITOTIC FIGURE DETECTOR AND COUNTER SYSTEM AND METHOD FOR DETECTING AND COUNTING MITOTIC FIGURES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/003041 International Application No.: PCT/US2009/049484
Publication Date: 07.01.2010 International Filing Date: 02.07.2009
IPC:
G06T 7/00 (2006.01) ,G06K 9/00 (2006.01) ,G06F 15/00 (2006.01)
G PHYSICS
06
COMPUTING; CALCULATING; COUNTING
T
IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
7
Image analysis, e.g. from bit-mapped to non bit-mapped
G PHYSICS
06
COMPUTING; CALCULATING; COUNTING
K
RECOGNITION OF DATA; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
9
Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
G PHYSICS
06
COMPUTING; CALCULATING; COUNTING
F
ELECTRIC DIGITAL DATA PROCESSING
15
Digital computers in general; Data processing equipment in general
Applicants:
NEC LABORATORIES AMERICA, INC. [US/US]; 4 Independence Way Suite 200 Princeton, NJ 08540, US (AllExceptUS)
Inventors:
COSATTO, Eric; US
BURGER, Harold, Christopher; US
MILLER, Matthew, L.; US
Agent:
KOLODKA, Joseph; US
Priority Data:
61/077,96603.07.2008US
Title (EN) MITOTIC FIGURE DETECTOR AND COUNTER SYSTEM AND METHOD FOR DETECTING AND COUNTING MITOTIC FIGURES
(FR) DÉTECTEUR DE FIGURE MITOTIQUE ET SYSTÈME DE COMPTEUR AINSI QUE PROCÉDÉ DE DÉTECTION ET DE COMPTAGE DE FIGURES MITOTIQUES
Abstract:
(EN) A method and system for detecting and counting mitotic figures in an image of a biopsy sample stained with at least one dye, includes color filtering the image in a computer process to identify pixels in the image that have a color which is indicative a mitotic figure; extracting the mitotic pixels in the image that are connected to one another in a computer process, thereby producing blobs of mitotic pixels; shape-filtering and clustering the blobs of mitotic pixels in a computer process to produce mitotic figure candidates; extracting sub-images of mitotic figures by cropping the biopsy sample image at the location of the blobs; extracting two sets of features from the mitotic figure candidates in two separate computer processes; determining which of the mitotic figure candidates are mitotic figures in a computer classification process based on the extracted sets of features; and counting the number of mitotic figures per square unit of biopsy sample tissue.
(FR) La présente invention concerne un procédé et un système de détection et de comptage de figures mitotiques sur une image d’un échantillon de biopsie coloré avec au moins un colorant, qui comprend la filtration chromatique de l’image au cours d’un processus informatique pour identifier les pixels sur l’image qui ont une couleur indiquant une figure mitotique ; l’extraction des pixels mitotiques sur l’image qui sont connectés les uns aux autres dans un processus informatique, produisant ainsi des taches de pixels mitotiques ; le filtrage des formes et le rassemblement des taches de pixels mitotiques dans un processus informatique pour produire des figures mitotiques candidates ; l’extraction de sous-images de figures mitotiques par recadrage de l’image de l’échantillon de biopsie au niveau de l’emplacement des taches ; l’extraction de deux jeux de caractéristiques des figures mitotiques candidates dans deux processus informatiques séparés ; la détermination des figures mitotiques candidates qui sont des figures mitotiques dans un processus de classification informatique basé sur les jeux de caractéristiques extraits ; et le comptage du nombre de figures mitotiques par unité carrée de tissu d’échantillons de biopsie.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)