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1. WO2010001407 - SYNTHESIS OF 11-(4-[2-(2-HYDROXYETHOXY)ETHYL]- PIPERAZINYL)DIBENZO[B,F][1,4]THIAZEPINE AND ITS FUMARATE SALT

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Publication Number WO/2010/001407
Publication Date 07.01.2010
International Application No. PCT/IN2009/000315
International Filing Date 01.06.2009
Chapter 2 Demand Filed 23.12.2009
IPC
C07D 267/02 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
267Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
02Seven-membered rings
CPC
C07D 417/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
02containing two hetero rings
04directly linked by a ring-member-to-ring-member bond
Applicants
  • INOGENT LABORATORIES PRIVATE LIMITED [IN]/[IN] (AllExceptUS)
  • REDDY, Reguri, Buchir [IN]/[IN] (UsOnly)
  • RAY, Purna, Chandra [IN]/[IN] (UsOnly)
  • REDDY, Ghanta, Mahesh [IN]/[IN] (UsOnly)
  • SATYANARAYANA, Kurma, Kota [IN]/[IN] (UsOnly)
  • NAGARAJU, Perumandla [IN]/[IN] (UsOnly)
  • VANAJARANI, Nallamothu [IN]/[IN] (UsOnly)
Inventors
  • REDDY, Reguri, Buchir
  • RAY, Purna, Chandra
  • REDDY, Ghanta, Mahesh
  • SATYANARAYANA, Kurma, Kota
  • NAGARAJU, Perumandla
  • VANAJARANI, Nallamothu
Agents
  • BABU, Ramesh, M.R.
Priority Data
1370/CHE/200805.06.2008IN
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SYNTHESIS OF 11-(4-[2-(2-HYDROXYETHOXY)ETHYL]- PIPERAZINYL)DIBENZO[B,F][1,4]THIAZEPINE AND ITS FUMARATE SALT
(FR) SYNTHÈSE DE LL-(4-[2-(2-HYDROXYÉTHOXY)ÉTHYL]- PIPÉRAZINYL)DIBENZO[B,F][1,4]THIAZÉPINE ET DE SES SELS DE FUMARATE
Abstract
(EN)
This invention broadly relates to a method for synthesizing ll-(4-[2-(2- hydroxyethoxy)ethyl]-piperazinyl)-dibenzo[b,f][l,4]thiazepine hemifumarate salt (Quetiapine hemifumarate) and the intermediate 11- piperazinyldibenzo[b,f][l,4]thiazepine dihydrochloride using phosphorous oxychloride in presence of non-aromatic solvent and condensing with piperazine.
(FR)
La présente invention concerne, d'une manière générale, un procédé de synthèse du sel d'hémifumarate de ll-(4-[2-(2- hydroxyéthoxy)éthyl]-pipérazinyl)-dibenzo[b,f][l,4]thiazépine (hémifumarate de Quetiapine) et de l'intermédiaire dichlorhydrate de 11-pipérazinyldibenzo[b,f][l,4]thiazépine en utilisant de l'oxychlorure de phosphore en présence d'un solvant non aromatique et en condensant avec de la pipérazine.
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