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1. WO2010000907 - GENOMIC FINGERPRINT OF MAMMARY CANCER

Publication Number WO/2010/000907
Publication Date 07.01.2010
International Application No. PCT/ES2009/070268
International Filing Date 01.07.2009
IPC
C12Q 1/68 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
C12N 15/12 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
12Genes encoding animal proteins
G01N 33/53 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
CPC
C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
C12Q 2600/106
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
C12Q 2600/118
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
118Prognosis of disease development
C12Q 2600/158
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
158Expression markers
C12Q 2600/16
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
16Primer sets for multiplex assays
G01N 33/57415
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
57407Specifically defined cancers
57415of breast
Applicants
  • CENTRO DE INVESTIGACIONES ENERGÉTICAS, MEDIOAMBIENTALES Y TECNOLÓGICAS (CIEMAT) [ES]/[ES] (AllExceptUS)
  • GARCÍA ESCUDERO, Ramón [ES]/[ES] (UsOnly)
  • PARAMIO GONZÁLEZ, Jesús María [ES]/[ES] (UsOnly)
  • MARTÍNEZ CRUZ, Ana Belén [ES]/[ES] (UsOnly)
  • SANTOS LAFUENTE, Mirentxu [ES]/[ES] (UsOnly)
Inventors
  • GARCÍA ESCUDERO, Ramón
  • PARAMIO GONZÁLEZ, Jesús María
  • MARTÍNEZ CRUZ, Ana Belén
  • SANTOS LAFUENTE, Mirentxu
Agents
  • ARIAS SANZ, Juan
Priority Data
P20080202402.07.2008ES
Publication Language Spanish (ES)
Filing Language Spanish (ES)
Designated States
Title
(EN) GENOMIC FINGERPRINT OF MAMMARY CANCER
(ES) HUELLA GENÓMICA DE CÁNCER DE MAMA
(FR) EMPREINTE GÉNOMIQUE DU CANCER DU SEIN
Abstract
(EN)
The present invention relates to in vitro methods for determining the prognosis of an individual diagnosed with mammary cancer developing metastasis or to select appropriate treatment for said individual. In particular, the invention relates to a gene signature expression whereof is correlated with the prognosis of an individual diagnosed with mammary cancer.
(ES)
La presente invención se relaciona con métodos in vitro para determinar el pronóstico de un sujeto diagnosticado de cáncer de mama a desarrollar metástasis o para seleccionar el tratamiento adecuado para dicho sujeto. En particular, la invención se refiere a una firma de genes cuya expresión está correlacionada con el pronóstico de un sujeto que ha sido diagnosticado de cáncer de mama.
(FR)
La présente invention concerne des procédés in vitro permettant de pronostiquer chez un sujet souffrant d'un cancer du sein le développement de métastases ou permettant de sélectionner le traitement approprié pour ce sujet. En particulier, l'invention concerne une signature génétique dont l'expression est corrélée au pronostic d'un sujet atteint d'un cancer du sein.
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