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1. WO2010000873 - MODIFICATION OF ALLERGENS FOR IMMUNOTHERAPY

Publication Number WO/2010/000873
Publication Date 07.01.2010
International Application No. PCT/EP2009/058533
International Filing Date 06.07.2009
IPC
A61K 39/35 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
35Allergens
A61K 39/36 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
35Allergens
36from pollen
A61P 37/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
08Antiallergic agents
CPC
A61K 2039/55505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55505Inorganic adjuvants
A61K 36/48
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
A61K 39/35
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
35Allergens
A61K 39/36
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
35Allergens
36from pollen
A61K 39/39
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
39characterised by the immunostimulating additives, e.g. chemical adjuvants
A61P 37/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
08Antiallergic agents
Applicants
  • HAL ALLERGY HOLDING B.V. [NL]/[NL] (AllExceptUS)
  • KOPPELMAN, Stefan Johan [NL]/[NL] (UsOnly)
  • VAN DEN HOUT, Robertus Henricus Joannes Alfonsus [NL]/[NL] (UsOnly)
  • SLEIJSTER-SELIS, Henriëtte Emilie [NL]/[NL] (UsOnly)
  • LUIJKX, Dionisius Marinus Antonius Maria [NL]/[NL] (UsOnly)
Inventors
  • KOPPELMAN, Stefan Johan
  • VAN DEN HOUT, Robertus Henricus Joannes Alfonsus
  • SLEIJSTER-SELIS, Henriëtte Emilie
  • LUIJKX, Dionisius Marinus Antonius Maria
Agents
  • VAN KOOIJ, Adriaan
Priority Data
08159687.604.07.2008EP
61/086,42005.08.2008US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MODIFICATION OF ALLERGENS FOR IMMUNOTHERAPY
(FR) MODIFICATION D'ALLERGÈNES POUR L'IMMUNOTHÉRAPIE
Abstract
(EN)
The present invention relates to pharmaceutical compositions for immunotherapy, for example for immunotherapy of peanut allergy. Further, the present invention relates to methods for the preparation of the present pharmaceutical compositions for immunotherapy, and their use in immunotherapy. Furthermore, the present invention relates to processes for modifying allergens thereby enhancing their application in immunotherapy. The invention also relates to the present modified allergens and pharmaceutical compositions comprising the present allergens, as well as to the use thereof in immunotherapy. According to a particularly preferred embodiment, the present invention relates to pharmaceutical compositions for immunotherapy comprising reduced and alkylated naturally occurring peanut allergens Ara h2 and/or Ara h6, or derivates or isoforms thereof wherein said pharmaceutical composition substantially does not comprise Ara h1 and/or Ara h3.
(FR)
La présente invention concerne des compositions pharmaceutiques pour l'immunothérapie, par exemple pour l'immunothérapie de l'allergie à l'arachide. De plus, la présente invention concerne des procédés pour la préparation des présentes compositions pharmaceutiques pour l'immunothérapie, et leur utilisation en immunothérapie. De plus, la présente invention concerne des procédés pour modifier des allergènes de manière à améliorer leur application en immunothérapie. L'invention concerne en outre les présents allergènes modifiés et des compositions pharmaceutiques comprenant les présents allergènes, ainsi que l'utilisation de ceux-ci en immunothérapie. Selon un mode de réalisation particulièrement préféré, la présente invention concerne des compositions pharmaceutiques pour immunothérapie comprenant des allergènes d'arachide d'origine naturelle réduits et alkylés Ara h2 et/ou Ara h6, ou des dérivés ou des isoformes de ceux-ci, ladite composition pharmaceutique ne contenant sensiblement pas Ara h1 et/ou Ara h3.
Latest bibliographic data on file with the International Bureau