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1. (WO2009156858) MOLECULAR SIGNATURE OF LIVER TUMOR GRADE AND USE TO EVALUATE PROGNOSIS AND THERAPEUTIC REGIMEN

Pub. No.:    WO/2009/156858    International Application No.:    PCT/IB2009/006450
Publication Date: Thu Dec 31 00:59:59 CET 2009 International Filing Date: Sat Jun 27 01:59:59 CEST 2009
IPC: C12Q 1/68
Applicants: INSTITUT PASTEUR
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
BUENDIA, Marie, Annick
ARMENGOL NIELL, Carolina
CAIRO, Stefano
DE REYNIES, Aurélien
Inventors: BUENDIA, Marie, Annick
ARMENGOL NIELL, Carolina
CAIRO, Stefano
DE REYNIES, Aurélien
Title: MOLECULAR SIGNATURE OF LIVER TUMOR GRADE AND USE TO EVALUATE PROGNOSIS AND THERAPEUTIC REGIMEN
Abstract:
The present invention concerns a method to determine the gene expression profile on a sample previously obtained from a patient diagnosed for a liver tumor, comprising assaying the expression of a set of genes in this sample and determining the gene expression profile (signature). In a particular embodiment, said method enables to determine the grade of the liver tumor, such as hepatoblastoma (HB) or a hepatocellular carcinoma (HCC). The invention is also directed to kits comprising a plurality of pairs of primers or a plurality of probes specific for a set of genes, as well as to solid support or composition comprising a set of probes specific for a set of genes. These methods are useful to determine the grade of a liver tumor in a sample obtained from a patient, to determine the risk of developing metastasis and/or to define the therapeutic regimen to apply to a patient.